DR. MICHAEL R KNOWLES, MD
Osteopathic Medicine at Manning Dr, Chapel Hill, NC
License number
North Carolina 17381
Category
Osteopathic Medicine
Type
Pulmonary Disease
Address
Address
101 Manning Dr, Chapel Hill, NC 27599
Phone
(919) 966-4996
(919) 843-5515 (Fax)
(919) 843-5515 (Fax)
Organization information
See more information about MICHAEL R KNOWLES at bizstanding.comMichael R Knowles MD
102 Mason Farm Rd #3, Chapel Hill, NC 27599
Categories:
Physicians & Surgeons
Phone:
(919) 966-6838 (Phone)
Unc Clinic - Michael R Knowles MD
101 Manning Dr #7001J, Chapel Hill, NC 27514
Categories:
Internal Medicine Physicians & Surgeons, Physicians & Surgeons, Pulmonary & Respiratory Physicians & Surgeons
Phone:
(919) 966-7890 (Phone)
University Of North Carolina - Michael R Knowles MD
7019 Thurston Bowles, Chapel Hill, NC 27599
Categories:
Internal Medicine Physicians & Surgeons
Phone:
(919) 966-6780 (Phone)
Professional information
Michael R Knowles, Chapel Hill NC
Specialties:
Pulmonologist
Address:
101 Manning Dr, Chapel Hill, NC 27514
7019 Thurston Bowles, Chapel Hill, NC 27599
7019 Thurston Bowles, Chapel Hill, NC 27599
Education:
University of North Carolina, School of Medicine - Doctor of Medicine
North Carolina Children's Hospital - Fellowship - Pulmonary Disease (Internal Medicine)
Duke University Hospital - Residency - Family Medicine
Duke University Hospital - Residency - Internal Medicine
North Carolina Children's Hospital - Fellowship - Pulmonary Disease (Internal Medicine)
Duke University Hospital - Residency - Family Medicine
Duke University Hospital - Residency - Internal Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine, American Board of Internal Medicine Sub-certificate in Pulmonary Disease (Internal Medicine)
Dr. Michael R Knowles, Chapel Hill NC - MD (Doctor of Medicine)
Specialties:
Pulmonology
Address:
7019 Thurston Bowles, Chapel Hill 27599
101 Manning Dr, Chapel Hill 27514
(919) 966-4996 (Phone), (919) 843-5515 (Fax)
101 Manning Dr, Chapel Hill 27514
(919) 966-4996 (Phone), (919) 843-5515 (Fax)
Certifications:
Internal Medicine, 1974, Pulmonary Disease, 1980
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
University of North Carolina At Chapel Hill
Graduated: 1971
The Ohio State University Hospitals
Duke University Hospital
U Nc Sch Med
University of North Carolina At Chapel Hill
Graduated: 1971
The Ohio State University Hospitals
Duke University Hospital
U Nc Sch Med
Michael Ray Knowles, Chapel Hill NC
Specialties:
Internal Medicine, Pulmonary Disease
Work:
Governors Village
101 Manning Dr, Chapel Hill, NC 27514
101 Manning Dr, Chapel Hill, NC 27514
Education:
University of North Carolina (1971)
Dr. Michael Knowles, Chapel Hill NC - DMD (Doctor of Dental Medicine)
Specialties:
Dentistry
Address:
University NC Plmnry Critcl Med
130 Mason Farm Rd STE 4124, Chapel Hill 27599
(919) 966-2531 (Phone)
130 Mason Farm Rd STE 4124, Chapel Hill 27599
(919) 966-2531 (Phone)
Languages:
English
Education:
Medical School
No Information Available As To Scientific Medical Education
No Information Available As To Scientific Medical Education
Identification Of Genetic Variants Associated With Increased Severity Of Pulmonary Disease
US Patent:
2009016, Jun 25, 2009
Filed:
Nov 3, 2008
Appl. No.:
12/264165
Inventors:
Mitchell Drumm - Brecksville OH, US
Rebecca Darrah - Strongsville OH, US
Paul Smith - Mayfield Village OH, US
Steven Martin - Shawnee KS, US
Michael Knowles - Chapel Hill NC, US
Steven Strausbaugh - Novelty OH, US
Robert Schilz - Shaker Heights OH, US
Rebecca Darrah - Strongsville OH, US
Paul Smith - Mayfield Village OH, US
Steven Martin - Shawnee KS, US
Michael Knowles - Chapel Hill NC, US
Steven Strausbaugh - Novelty OH, US
Robert Schilz - Shaker Heights OH, US
Assignee:
CASE WESTERN RESERVE UNIVERSITY - Cleveland OH
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
A method of determining a genetic component contributing to the severity of a pulmonary disease in a patient comprises determining the presence or absence of one or more single nucleotide polymorphisms (SNPs) in the Endothelin Receptor A (EDNRA) gene or the Interleukin-8 (IL-8) gene of the patient. The SNPs are rs5335 or rs1801708 for EDNRA, or rs4O73 for IL-8. The pulmonary disease may be cystic fibrosis or lymphangioleimyomatosis. Determining the presence or absence of one or more of SNPs rs5335 or rs1801708 in the EDNRA gene or rs4073 in the IL-8 gene of the patient may also be used in a method of treating a patient having a pulmonary disease. A kit may comprise one or more probes for determining the presence or absence of one or more of SNPs rs5335 and rs1801708 in the EDNRA gene or the SNP rs4073 in the IL-8 gene.
Methods And Compositions For Detecting Genetic Markers Associated With Primary Ciliary Dyskinesia
US Patent:
2010029, Nov 18, 2010
Filed:
May 14, 2010
Appl. No.:
12/780220
Inventors:
Maimoona Banoo Abdul Hamid Zariwala - Chapel Hill NC, US
Michael R. Knowles - Chapel Hill NC, US
Michael R. Knowles - Chapel Hill NC, US
International Classification:
C40B 30/02, G01N 33/50, C12Q 1/68, G01N 23/00, G01N 30/00
US Classification:
506 8, 436 94, 435 6, 250307, 73 6152
Abstract:
The present invention provides methods and compositions for detecting mutations in a DNAH11 gene of a subject to diagnose primary ciliary dyskinesia (PCD) in the subject and/or to identify a subject as having an increased risk of having PCD and/or to identify a carrier of a PCD mutation.
Method Of Administering Amiloride
US Patent:
5725842, Mar 10, 1998
Filed:
Jan 5, 1996
Appl. No.:
8/583671
Inventors:
Richard C. Boucher - Chapel Hill NC
Michael R. Knowles - Chapel Hill NC
Michael R. Knowles - Chapel Hill NC
Assignee:
The University of North Carolina at Chapel Hill - Chapel Hill NC
International Classification:
A61K 912
US Classification:
424 45
Abstract:
Methods are disclosed for removing retained mucus secretions from the lungs of a human subject. The method includes (1) generating an aerosol suspension of respirable solid, dry particulate amiloride, and (2) delivering by inhalation the aerosol suspension to the respiratory system of the subject. The solid particulate amiloride is comprised of particles of about 1 to 5 microns and is free of liquid amiloride particles. The aerosol suspension of respirable solid particulate amiloride is administered in an amount sufficient to achieve concentrations of amiloride on the airway surfaces of from about 10. sup. -7 to 10. sup. -3 Moles/liter. As a result of the treatment, the secretions are hydrated and more easily transported from the lung via mucociliary action. Methods are also disclosed for the treatment of cystic fibrosis in humans.
Genetic Modifiers Of Cystic Fibrosis
US Patent:
2013027, Oct 17, 2013
Filed:
Sep 30, 2011
Appl. No.:
13/876712
Inventors:
Lisa Strug - Toronto, CA
Lei Sun - Toronto, CA
Johanna M. Rommens - Toronto, CA
Garry Cutting - Towson MD, US
Michael Knowles - Chapel Hill NC, US
Mitchell L. Drumm - Brecksville OH, US
Peter Durie - Toronto, CA
Lei Sun - Toronto, CA
Johanna M. Rommens - Toronto, CA
Garry Cutting - Towson MD, US
Michael Knowles - Chapel Hill NC, US
Mitchell L. Drumm - Brecksville OH, US
Peter Durie - Toronto, CA
Assignee:
Hospital for Sick Children - Toronto ON
Case Western Reserve University - Cleveland OH
Univeristy of North Carolina at Chapet Hill - Chapel Hill NC
The Johns Hopkins University - Baltimore MD
Case Western Reserve University - Cleveland OH
Univeristy of North Carolina at Chapet Hill - Chapel Hill NC
The Johns Hopkins University - Baltimore MD
International Classification:
C12Q 1/68
US Classification:
506 9, 435 611
Abstract:
Disclosed herein are compositions and methods for and treating Cystic Fibrosis lung disease severity and/or secondary manifestations, including meconium ileus and CF related liver disease.
Aerosolized Amiloride Treatment Of Retained Pulmonary Secretions
US Patent:
4501729, Feb 26, 1985
Filed:
Dec 13, 1982
Appl. No.:
6/449424
Inventors:
Richard C. Boucher - Chapel Hill NC
John T. Gatzy - Chapel Hill NC
Michael R. Knowles - Chapel Hill NC
John T. Gatzy - Chapel Hill NC
Michael R. Knowles - Chapel Hill NC
Assignee:
Research Corporation - New York NY
International Classification:
A61K 31495
US Classification:
424 45
Abstract:
This disclosure describes a method of treatment of retained pulmonary secretions by the use of aerosolized suspension of amiloride.