Inventors:
David M. Lucas - Hilliard OH, US
Mark R. Parthun - Hilliard OH, US
John C. Byrd - Columbus OH, US
Michael R. Grever - Columbus OH, US
Assignee:
The Ohio State University - Columbus OH
International Classification:
A61K 3144
Abstract:
The invention provides methods for treating a patient with chronic lymphocytic leukemia of B cells (B-CLL). One method comprises administering to a patient with B-CLL, one or more benzamide derivatives, the benzamide derivatives including MS-275 and related compounds. Another method comprises administering to a patient with B-CLL, one or more of the benzamide derivatives, and additionally administering to the patient one or more antibodies immunospecific for 1D10 antigen. Additional methods for inducing apoptosis of B-CLL cells and for increasing expression of 1D10 antigen in B-CLL cells using the benzamide derivatives are also provided.