Inventors:
Robert Lance Wells - Athens GA, US
Ronald C. Orlando - Athens GA, US
Stephen Dalton - Athens GA, US
Kelley W. Moreman - Bishop GA, US
Michael J. Pierce - Athens GA, US
Michael Tiemeyer - Watkinsville GA, US
William S. York - Watkinsville GA, US
Assignee:
University of Georgia Research Foundation, Inc. - Athens GA
International Classification:
C12Q 1/70, C12Q 1/02
Abstract:
The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative/comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and/or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.