Inventors:
Richard A. Nugent - Galesburg MI
Stephen T. Schlachter - Boulder CO
Michael J. Murphy - Kalamazoo MI
Joel Morris - Kalamazoo MI
Richard C. Thomas - Kalamazoo MI
Donn G. Wishka - Kalamazoo MI
Gary J. Cleek - Kalamazoo MI
David R. Graber - Kalamazoo MI
Assignee:
Pharmacia & Upjohn Company - Kalamazoo MI
International Classification:
C07D23946, C07D23956, C07D23948, A61K 31505
Abstract:
The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R. sub. 4 is selected from the group consisitng of --H or --NR. sub. 15 R. sub. 16 where R. sub. 15 is --H and R. sub. 16 is --H, C. sub. 1 -C. sub. 6 alkyl, NH. sub. 2 or R. sub. 15 and R. sub. 16 taken together with the --N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R. sub. 6 is selected from the group consisting of --H, or halo (preferably --Cl); with the overall proviso that R. sub. 4 and R. sub. 6 are not both --H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase. ##STR1##.