MICHAEL MILBURN, MD
Osteopathic Medicine at Lawrence Expy, Santa Clara, CA
License number
California G79804
Category
Osteopathic Medicine
Type
Sports Medicine
Address
Address
2
710 Lawrence Expy, Santa Clara, CA 95051
1800 Harrison St FL 7, Oakland, CA 94612
1800 Harrison St FL 7, Oakland, CA 94612
Phone
(408) 236-6400
(510) 625-6262
(510) 625-6262
Professional information
Michael Robert Milburn, Santa Clara CA
Specialties:
Internist
Address:
710 Lawrence Expy, Santa Clara, CA 95051
Education:
Doctor of Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine, American Board of Internal Medicine Sub-certificate in Sports Medicine (Internal Medicine)
Michael Robert Milburn, Santa Clara CA
Specialties:
Internal Medicine, Sports Medicine
Work:
Santa Clara Homestead Med Center
710 Lawrence Expy, Santa Clara, CA 95051
710 Lawrence Expy, Santa Clara, CA 95051
Education:
University of California at Davis (1993)
Methods For The Design Of Molecular Scaffolds And Ligands
US Patent:
2004017, Sep 2, 2004
Filed:
Feb 28, 2003
Appl. No.:
10/377268
Inventors:
Klaus-Peter Hirth - San Francisco CA, US
Michael Milburn - Emeryville CA, US
Michael Milburn - Emeryville CA, US
Assignee:
Plexxikon, Inc.
International Classification:
G01N033/53, G06F019/00, G01N033/48, G01N033/50
US Classification:
435/007100, 702/019000
Abstract:
The present invention provides methods of designing ligands that specifically bind to target molecules by testing a set of distinct compounds to identify compound that bind to member of a molecular family of interest. Those compounds that show binding activity can be used as a starting point for ligand design. Unlike previous methods, even compounds that bind with only low affinity are of interest and can be used. Common chemical structures of binding molecules including low affinity binding molecules are identified, thereby providing molecular scaffolds. Co-crystals of the protein and the molecular scaffolds can be formed and analyzed by X-ray crystallography to determine the orientation of the scaffold compounds at the binding site of the molecule. Using the orientation information on a scaffold at the binding site of the molecule, chemically tractable structures of the scaffold are identified that are modified to provide ligands that bind to the target molecule with altered binding affinity or specificity to a target molecule or to members of a molecular family. New and useful ligands can therefore be designed in a rational manner and with a minimum investment of resources using the methods provided.
Ppar Active Compounds
US Patent:
7202266, Apr 10, 2007
Filed:
Jul 16, 2004
Appl. No.:
10/893134
Inventors:
James Arnold - West Chester PA, US
Dean R. Artis - Kensington CA, US
Clarence R. Hurt - San Ramon CA, US
Prabha N. Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael V. Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US
Dean R. Artis - Kensington CA, US
Clarence R. Hurt - San Ramon CA, US
Prabha N. Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael V. Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US
Assignee:
Plexxikon, Inc. - Berkeley CA
International Classification:
A61K 209/08, C07D 209/08
US Classification:
514414, 514419, 548466, 548494
Abstract:
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
Ppar Active Compounds
US Patent:
7348338, Mar 25, 2008
Filed:
Sep 8, 2004
Appl. No.:
10/937791
Inventors:
James Arnold - West Chester PA, US
Dean R. Artis - Kensington CA, US
Clarence R. Hurt - San Ramon CA, US
Prabha N. Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael V. Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US
Dean R. Artis - Kensington CA, US
Clarence R. Hurt - San Ramon CA, US
Prabha N. Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael V. Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US
Assignee:
Plexxikon, Inc. - Berkeley CA
International Classification:
A61K 31/44, A61K 31/4725, A61K 31/404
US Classification:
514300, 514310, 514313, 514339, 514415
Abstract:
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
Ppar Active Compounds
US Patent:
8367828, Feb 5, 2013
Filed:
Apr 28, 2010
Appl. No.:
12/768729
Inventors:
James Arnold - West Chester PA, US
Dean R. Artis - Kensington CA, US
Clarence R. Hurt - San Ramon CA, US
Prabha N. Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael V. Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US
Dean R. Artis - Kensington CA, US
Clarence R. Hurt - San Ramon CA, US
Prabha N. Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael V. Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US
Assignee:
Plexxikon Inc. - Berkeley CA
International Classification:
C07D 471/04
US Classification:
546113, 546118
Abstract:
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
Ppar Active Compounds
US Patent:
2008004, Feb 21, 2008
Filed:
Feb 27, 2007
Appl. No.:
11/679792
Inventors:
James Arnold - West Chester PA, US
Dean Artis - Kensington CA, US
Clarence Hurt - San Ramon CA, US
Prabha Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US
Dean Artis - Kensington CA, US
Clarence Hurt - San Ramon CA, US
Prabha Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US
International Classification:
A61K 31/404, A61P 3/00, A61P 35/00, A61P 9/00, C07D 209/18, C07D 409/12
US Classification:
514414000, 514419000, 548465000, 548494000
Abstract:
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
Pyk2 Crystal Structure And Uses
US Patent:
2005017, Aug 4, 2005
Filed:
Feb 27, 2004
Appl. No.:
10/789818
Inventors:
Prabha Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Abhinav Kumar - Pleasant Hill CA, US
Michael Milburn - Emeryville CA, US
Yoshihisa Suzuki - El Sobrante CA, US
Heike Krupka - Hayward CA, US
Abhinav Kumar - Pleasant Hill CA, US
Michael Milburn - Emeryville CA, US
Yoshihisa Suzuki - El Sobrante CA, US
International Classification:
G01N033/53, C07K016/40
US Classification:
435007100, 530388260
Abstract:
A crystal structure of PYK2 is described that was determined by X-ray crystallography. The use of PYK2 crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate PYK2.
Ppar Active Compounds
US Patent:
2007014, Jun 28, 2007
Filed:
Feb 27, 2007
Appl. No.:
11/679777
Inventors:
James Arnold - West Chester PA, US
Dean Artis - Kensington CA, US
Clarence Hurt - San Ramon CA, US
Prabha Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US
Dean Artis - Kensington CA, US
Clarence Hurt - San Ramon CA, US
Prabha Ibrahim - Mountain View CA, US
Heike Krupka - Hayward CA, US
Jack Lin - Hercules CA, US
Michael Milburn - Emeryville CA, US
Weiru Wang - Lafayette CA, US
Chao Zhang - Moraga CA, US
International Classification:
C07D 209/18, A61K 31/405
US Classification:
514418000, 548495000
Abstract:
Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
Crystal Structure Of Pim-1 Kinase
US Patent:
2004014, Jul 22, 2004
Filed:
Sep 16, 2003
Appl. No.:
10/664421
Inventors:
Ryan Bremer - Oakland CA, US
Prabha Ibrahim - Mountain View CA, US
Abhinav Kumar - Pleasant Hill CA, US
Valsan Mandiyan - Bloomfield NJ, US
Michael Milburn - Emeryville CA, US
Prabha Ibrahim - Mountain View CA, US
Abhinav Kumar - Pleasant Hill CA, US
Valsan Mandiyan - Bloomfield NJ, US
Michael Milburn - Emeryville CA, US
Assignee:
Plexxikon, Inc.
International Classification:
G01N033/53, A61K038/00
US Classification:
514/012000, 435/007100
Abstract:
A crystal structure of PIM-1 is described that was determined by X-ray crystallography. The use of PIM-1 crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate PIM-1 and other PIM kinases.