Inventors:
Seth Hetherington - Alpharetta GA, US
Arlene R Hughes - Durham NC, US
Eric H Lai - Durham NC, US
Michael Mosteller, Jr. - Durham NC, US
Denise D Shortino - Durham NC, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
C12Q 1/68, C12P 19/34, C07H 21/02, C07H 21/04
US Classification:
435 6, 435 911, 435 912, 536 243
Abstract:
Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for polymorphisms in the TNFα gene, the class 1 HLA genes, or a combination of both the TNFα and HLA genes.