MICHAEL MATEIU GRUNSTEIN
Medical Practice in Merion Station, PA
License number
Pennsylvania MD038136E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Merion Station, PA 19066
Personal information
See more information about MICHAEL MATEIU GRUNSTEIN at radaris.comName
Address
Phone
340 Sycamore Ave, Merion Sta, PA 19066
34 Sycamore Ave, Merion, PA 19066
340 Sycamore Ave, Merion Sta, PA 19066
Merion Station, PA
Professional information
Compositions And Methods For Treatment Of Asthma
US Patent:
6630140, Oct 7, 2003
Filed:
Mar 3, 1999
Appl. No.:
09/261104
Inventors:
Michael M. Grunstein - Merion PA
Hakon Hakonarson - Reykjavic, IS
Hakon Hakonarson - Reykjavic, IS
Assignee:
The Childrens Hospital of Philadelphia - Philadelphia PA
International Classification:
A61K 39395
US Classification:
4241331, 4241431, 514 2
Abstract:
Methods of treating or preventing induction of asthma in a human patient are provided. The methods comprise administering to the human an anti-Fc RII receptor protein ligand suspended in a pharmaceutically acceptable carrier in an amount sufficient to inhibit binding of IgE to an anti-Fc RII receptor protein thereby treating or preventing induction of asthma in the human.
Methods And Apparatus For Measuring Infant Lung Function And Providing Respiratory System Therapy
US Patent:
5261397, Nov 16, 1993
Filed:
May 10, 1991
Appl. No.:
7/698401
Inventors:
Michael M. Grunstein - Merion PA
Assignee:
The Children's Hospital of Philadelphia - Philadelphia PA
International Classification:
A61M 1600
US Classification:
12820418
Abstract:
Methods and apparatus for determining respiratory system compliance (C. sub. rs) and resistance (R. sub. rs) are disclosed. The present invention provides apparatus whereby an airflow is introduced to a patient via a set of one way valves such that the inspiratory and expiratory flow paths are separate. By selectively occluding expiration, C. sub. rs can be determined and, following subsequent release of the occlusion, the respiratory system time constant (. tau. sub. rs) is measured, from which R. sub. rs can be derived. In another embodiment, by selectively occluding inspiration after expiration has been occluded, a drop in pressure due to the compliance of the lungs can be measured and from this and other data, another measure of R. sub. rs can be obtained. The introduction of an airflow into the patient permits the present invention to obtain passive and dynamic respiratory function data.
Methods For Producing Ex Vivo Models For Inflammatory Disease And Uses Thereof
US Patent:
7435548, Oct 14, 2008
Filed:
Jul 16, 2007
Appl. No.:
11/879066
Inventors:
Hakon Hakonarson - Revkjavik, IS
Michael M. Grunstein - Merion PA, US
Michael M. Grunstein - Merion PA, US
Assignee:
deCODE genetics ehf. - Reykjavik
The Children's Hospital of Philadelphia - Philadelphia PA
The Children's Hospital of Philadelphia - Philadelphia PA
International Classification:
C12Q 1/68, G01N 33/53
US Classification:
435 6, 435 724
Abstract:
The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e. g. , IL-β, TNFα or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.
Methods For Producing Ex Vivo Models For Inflammatory Disease And Uses Thereof
US Patent:
7244571, Jul 17, 2007
Filed:
Dec 22, 2004
Appl. No.:
11/022564
Inventors:
Hakon Hakonarson - Reykjavik, IS
Michael M. Grunstein - Merion PA, US
Michael M. Grunstein - Merion PA, US
Assignee:
deCODE genetics ehf. - Rreykjavik
The Children's Hospital of Philadelphia - Philadelphia PA
The Children's Hospital of Philadelphia - Philadelphia PA
International Classification:
C12Q 1/68, G01N 33/53
US Classification:
435 6, 435 724
Abstract:
The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e. g. , IL-1β, TNFα or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.
Methods For Producing Ex Vivo Models For Inflammatory Disease And Uses Thereof
US Patent:
6893828, May 17, 2005
Filed:
Sep 6, 2001
Appl. No.:
09/947954
Inventors:
Hakon Hakonarson - Reykjavik, IS
Michael M. Grunstein - Merion PA, US
Michael M. Grunstein - Merion PA, US
Assignee:
deCODE genetics ehf. - Reykjavik
The Children's Hospital of Philadelphia - Philadelphia PA
The Children's Hospital of Philadelphia - Philadelphia PA
International Classification:
G01N033/53, G01N033/567
US Classification:
435 721, 435 71, 435 72, 435 724
Abstract:
The present invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with IL-1β, TNFα or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to methods for identifying genes that correlate with various pro-asthma/pro-inflammatory disease phenotypes.
Compositions And Methods Which Modulate G-Protein Signaling For The Treatment Of Inflammatory Disorders Such As Asthma And Allergic Conjunctivitis
US Patent:
2014005, Feb 20, 2014
Filed:
Oct 29, 2013
Appl. No.:
14/065954
Inventors:
Michael M. Grunstein - Merion Station PA, US
Assignee:
The Children's Hospital of Philadelphia - Philadelphia PA
International Classification:
A61K 38/16
US Classification:
514 187, 514 208, 514 213
Abstract:
Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.
Methods Employing Agonists Of P38 Map Kinase For The Treatment Of Asthma
US Patent:
2005027, Dec 15, 2005
Filed:
May 23, 2005
Appl. No.:
11/135221
Inventors:
Michael Grunstein - Merion Station PA, US
International Classification:
A61K031/704, A61K031/573
US Classification:
514035000, 514171000
Abstract:
Methods for treating asthma using agonists of p38 are disclosed. Also provided are screening methods to identify test compounds which have efficacy for the treatment of asthma.
Composition And Methods For Treatment Asthma
US Patent:
2005007, Apr 14, 2005
Filed:
Aug 21, 2003
Appl. No.:
10/645913
Inventors:
Michael Grunstein - Merion PA, US
Hakon Hakonarson - Reykjavic, IS
Hakon Hakonarson - Reykjavic, IS
International Classification:
A61K039/395
US Classification:
424144100, 424141100
Abstract:
Methods of treating or preventing induction of asthma in a human patient are provided. The methods comprise administering to the human an anti-FcεRII receptor protein ligand suspended in a pharmaceutically acceptable carrier in an amount sufficient to inhibit binding of IgE to an anti-FcεRII receptor protein thereby treating or preventing induction of asthma in the human.
Compositions And Methods Which Modulate G-Protein Signaling For The Treatment Of Inflammatory Disorders Such As Asthma And Allergic Conjunctivitis
US Patent:
8569229, Oct 29, 2013
Filed:
Aug 9, 2010
Appl. No.:
12/852711
Inventors:
Michael M. Grunstein - Merion Station PA, US
Assignee:
The Children's Hospital of Philadelphia - Philadelphia PA
International Classification:
A61K 38/00, A61P 11/06, A61P 11/08, C07K 14/72, A61K 9/12
US Classification:
514 17, 514 206, 514 213, 424 45, 930 10, 930300, 530324
Abstract:
Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.
Methods For Treatment Of Asthma
US Patent:
2004003, Feb 26, 2004
Filed:
May 28, 2003
Appl. No.:
10/447091
Inventors:
Michael Grunstein - Merion PA, US
International Classification:
A61K038/20, A61K031/573
US Classification:
424/085100, 514/171000, 424/085200
Abstract:
Methods combining glucocorticoids and cytokines for the treatment of inflammatory disorders are disclosed.