MICHAEL KAPLITT, MD
Medical Practice at 68 St, New York, NY
License number
New York 210274
Category
Medical Practice
Type
Neurological Surgery
Address
Address
525 E 68Th St #99, New York, NY 10065
Phone
(212) 746-4966
Personal information
See more information about MICHAEL KAPLITT at radaris.comName
Address
Phone
1330 1St Ave APT 909, New York, NY 10021
350 E 82Nd St APT 10G, New York, NY 10028
1438 3Rd Ave, New York, NY 10028
504 63Rd St, New York, NY 10021
350 82Nd St, New York, NY 10028
Organization information
See more information about MICHAEL KAPLITT at bizstanding.comMichael Kaplitt MD,PHD
525 E 68 St, New York, NY 10065
Industry:
Neurosurgeon
Phone:
(212) 746-4966 (Phone)
Michael Gordon Kaplitt
Professional information
See more information about MICHAEL KAPLITT at trustoria.com
Associate Professor (Tenure) Of Neurological Surgery At Weill Cornell Medical College
Associate Professor (Tenure) Of Neurological Surgery At Weill Cornell Medical College
Position:
Associate Professor (Tenure) of Neurological Surgery at Weill Cornell Medical College
Location:
Greater New York City Area
Industry:
Higher Education
Work:
Weill Cornell Medical College
-
Associate Professor (Tenure) of Neurological Surgery
Defective Dna Viral Vector Comprising A Neural Tissue-Specific Promoter For In Vivo Expression Of A Gene
Defective Dna Viral Vector Comprising A Neural Tissue-Specific Promoter For In Vivo Expression Of A Gene
US Patent:
6040172, Mar 21, 2000
Filed:
Feb 14, 1995
Appl. No.:
8/381924
Inventors:
Michael G. Kaplitt - New York NY
Assignee:
The Rockefeller University - New York NY
International Classification:
C12N 1563, C12N 1500, C12N 1509, C12N 500
US Classification:
4353201
Abstract:
A replication defective DNA viral vector that comprises a gene of interest encoding a protein having a demonstrated therapeutic effect on a host cell is disclosed. The vector comprises the gene in operable linkage with a neural tissue-specific promoter, which is a promoter derived from a gene normally produced in the host cell. In particular an HSV-1 vector is used. A preferred DNA defective vector is the dvHBENK which includes a promoter prepared from the rat preproenkephalin gene, the promoter being in operable linkage with the lacZ gene. The disclosed DNA viral vector is useful for achieving stable in vivo long-term expression, in particular in mammalian brain cells.
Aav-Mediated Delivery Of Dna To Cells Of The Nervous System
Aav-Mediated Delivery Of Dna To Cells Of The Nervous System
US Patent:
6503888, Jan 7, 2003
Filed:
Apr 13, 2000
Appl. No.:
09/548176
Inventors:
Michael G. Kaplitt - New York NY
Matthew J. During - Weston CT
Matthew J. During - Weston CT
Assignee:
The Rockefeller University - New York NY
Yale University - New Haven CT
Yale University - New Haven CT
International Classification:
A01N 4304
US Classification:
514 44, 4353201, 435455, 435456
Abstract:
The invention relates to a method of delivering exogenous DNA to a target cell of the mammalian central nervous system using an adeno-associated virus (AAV)-derived vector. Also included in the invention are the AAV-derived vectors containing exogenous DNA which encodes a protein or proteins which prevent or treat nervous system disease, and a method of prevent or treating such disease.
Glutamic Acid Decarboxylase (Gad) Based Delivery System
Glutamic Acid Decarboxylase (Gad) Based Delivery System
US Patent:
6780409, Aug 24, 2004
Filed:
May 23, 2001
Appl. No.:
09/863179
Inventors:
Matthew J. During - Philadelphia PA
Michael Kaplitt - New York NY
Michael Kaplitt - New York NY
Assignee:
Thomas Jefferson University - Philadelphia PA
Neurologix, Inc. - New York NY
Neurologix, Inc. - New York NY
International Classification:
A01N 6300
US Classification:
424 932, 424 931, 4353201, 514 44
Abstract:
The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the subthalmic nucleus of the basal ganglia, mesaphilia and thalmus.
Expression Of Growth Associated Protein B-50/Gap-43 In Vitro And In Vivo
Expression Of Growth Associated Protein B-50/Gap-43 In Vitro And In Vivo
US Patent:
6106824, Aug 22, 2000
Filed:
Aug 2, 1996
Appl. No.:
8/691558
Inventors:
Michael G. Kaplitt - New York NY
Joost Verhaagen - Utrecht, NL
Joost Verhaagen - Utrecht, NL
Assignee:
The Rockefeller University - New York NY
Rudolf Magnus Institute
Rudolf Magnus Institute
International Classification:
A61K 4800, C12N 1512, C12N 1586
US Classification:
424 932
Abstract:
The present invention relates to a viral vector capable of the transfer and in vivo expression of growth-associated protein (B-50/GAP-43) in neuronal target cells of a mammalian host. The viral vector contains a recombinant DNA molecule comprising a B-50/GAP-43 gene operably associated with a promoter, which promoter controls short term, high level expression of the B-50/GAP-43 gene. Preferably, the viral vector is a defective viral vector, in particular a defective herpes virus or an adeno-associated virus. In a specific embodiment, defective herpesvirus, adenovirus, and adeno-associated virus viral vectors containing the rat B-50/GAP-43 gene under control of the human cytomegalovirus immediate early promoter have been prepared. The invention further provides a method for treating nerve damage in a subject. The method comprises introducing a vector comprising a B-50/GAP-43 gene operably associated with a promoter into a damaged nerve tissue of a subject.
Infusion Device And Method For Infusing Material Into The Brain Of A Patient
Infusion Device And Method For Infusing Material Into The Brain Of A Patient
US Patent:
8182460, May 22, 2012
Filed:
Feb 9, 2010
Appl. No.:
12/702470
Inventors:
Michael G. Kaplitt - New York NY, US
Matthew J. During - New York NY, US
Matthew J. During - New York NY, US
Assignee:
Medtronic, Inc. - Minneapolis MN
International Classification:
A61M 31/00
US Classification:
604500
Abstract:
A fluid infusion device and a method of using the same. The device includes an outer, flexible guide catheter having a distal end for introduction beneath the skull of a patient and a proximal end remaining external of the patient. A flexible infusion fiber is located within the guide catheter and has a distal end extending outwardly from the guide catheter to be located in a target area within the patient's brain. The infusion fiber can be fixed or axially movable within the guide catheter. In the latter embodiment, the proximal end of the infusion fiber extending outwardly from the guide catheter can be manipulated to locate the distal end of the infusion fiber in the target area. An infusion pump is connected to the proximal end of the infusion fiber to infuse a minute quantity of fluid at an extremely low flow rate into the brain of the patient.
Aav-Mediated Delivery Of Dna To Cells Of The Nervous System
Aav-Mediated Delivery Of Dna To Cells Of The Nervous System
US Patent:
6180613, Jan 30, 2001
Filed:
Jun 6, 1995
Appl. No.:
8/467044
Inventors:
Michael G. Kaplitt - New York NY
Matthew J. During - Weston CT
Matthew J. During - Weston CT
Assignee:
The Rockefeller University - New York NY
Yale University - New Haven CT
Yale University - New Haven CT
International Classification:
A01N 4304, A61K 3170, C12N 1563, C12N 1500
US Classification:
514 44
Abstract:
The invention relates to a method of delivering exogenous DNA to a target cell of the mammalian central nervous system using an adeno-associated virus (AAV)-derived vector. Also included in the invention are the AAV-derived vectors containing exogenous DNA which encodes a protein or proteins which treat nervous system disease, and a method of treating such disease.
Materials And Methods For Gene Mediated Therapy Of Psychiatric Disorders
Materials And Methods For Gene Mediated Therapy Of Psychiatric Disorders
US Patent:
8642341, Feb 4, 2014
Filed:
Oct 31, 2008
Appl. No.:
12/740725
Inventors:
Michael Kaplitt - New York NY, US
Brian L. Alexander - New York NY, US
Brian L. Alexander - New York NY, US
Assignee:
Cornell University - Ithaca NY
International Classification:
C12N 15/63, C12N 15/86, C12N 15/00
US Classification:
435455, 424 932, 424 936, 536 232, 536 241, 514 44
Abstract:
The invention provides materials and methods for p11-mediated therapy of psychiatric disorders. The invention provides vectors for increasing p11 expression and methods of treating a mammal with one or more symptoms of a psychiatric disorder. The invention also provides methods for improving a mammal's responsiveness to treatment for a psychiatric disorder. The invention further provides model animals for depression and depression therapy.
Glutamic Acid Decarboxylase (Gad) Based Delivery System
Glutamic Acid Decarboxylase (Gad) Based Delivery System
US Patent:
7645446, Jan 12, 2010
Filed:
Mar 16, 2004
Appl. No.:
10/802417
Inventors:
Matthew During - New York NY, US
Michael Kaplitt - New York NY, US
Michael Kaplitt - New York NY, US
Assignee:
Neurologix, Inc. - Fort Lee NJ
International Classification:
A01N 63/00, A01N 65/00, A61K 48/00
US Classification:
424 932, 424 931
Abstract:
The invention provide methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain that is overstimulated in neurodegenerative diseases. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding glutamic acid decarboxylase (GAD) to cells in the subthalmic nucleus of the basal ganglia, mesaphilia and thalamus.
Method For Generating Replication Defective Viral Vectors That Are Helper Free
Method For Generating Replication Defective Viral Vectors That Are Helper Free
US Patent:
8067156, Nov 29, 2011
Filed:
May 31, 2002
Appl. No.:
10/159968
Inventors:
Michael G. Kaplitt - New York NY, US
Sergei Moussatov - New York NY, US
Sergei Moussatov - New York NY, US
Assignee:
The Rockefeller University - New York NY
International Classification:
C12Q 1/70, C12Q 1/68, C12N 7/00, C12N 15/861, A01N 43/04, A61K 31/70
US Classification:
435 5, 435 6, 435456, 4352351, 4353201, 514 44
Abstract:
Sequences are provided that are capable of directing circular adeno-associated virus replication, useful in vectors for providing therapeutic agents to a subject in need thereof. The vectors of the invention are particularly useful in the treatment of acute medical conditions requiring rapid gene expression. Further provided are methods for producing packaged defective viral vectors.