MICHAEL JOSEPH WILLIAMS, M.D.
Radiology at Sotoyome St, Santa Rosa, CA

6488701, Dec 3, 2002

Mar 31, 1998

09/053145

John E. Nolting - Santa Rosa CA
Michael S. Williams - Santa Rosa CA
Matthew J. Birdsall - Santa Rosa CA
Robert D. Lashinski - Sebastopol CA
Samuel L. Shull - Santa Rosa CA

Medtronic AVE, Inc. - Santa Rosa CA

A61F 206

623 113, 623 123, 623 139, 623 146, 623 115

A stent-graft assembly having a thin-walled membrane and method of preparing the same are disclosed. In a first embodiment, the assembly comprises a stent, a coating and a porous membrane, wherein the membrane is less than 0. 040 inch thick or less. Portions of the coating extend into the pores of the thin membrane to sealingly engage the membrane to achieve secure adhesion. In a second embodiment the coating and thin membrane bond to form a homogenous structure. In an alternative embodiment, the assembly comprises an inner and outer thin membrane bound to one another through the interstices of the support member and a coating at the proximal and distal regions. In any of the foregoing embodiments, the proximal and distal regions of the stent-graft assembly may comprise an additional coating, whereby layers of material are sealed, thereby minimizing thrombogenic potential of free ends of the assembly.

2013001, Jan 17, 2013

Oct 25, 2011

13/281399

Richard A. Glenn - Santa Rosa CA, US
Jeffrey A. Smith - Petaluma CA, US
Geoffrey A. Orth - Sebastopol CA, US
Kevin Holbrook - Santa Rosa CA, US
Michael S. Williams - Santa Rosa CA, US

A61B 5/04, A61N 1/05

600381, 607116

An intravascular electrode device for use in neuromodulation includes an anchor expandable from a radially compressed position to a radially expanded position. A lead extends from the anchor and has at least one conductor extending through it. A flex circuit is coupled to the anchor and comprises a flexible insulative substrate, a plurality of electrodes carried by the substrate, and a plurality of conductive traces carried by the substrate, each trace electrically coupled to an electrode and a conductor. Expansion of the anchor within a blood vessel biases the electrodes into contact with the surrounding blood vessel wall. An exemplary anchor includes a first portion having expansion forces sufficient to bias the electrodes against the vessel wall for mapping and chronic stimulation, and a second portion having greater radial expansion forces sufficient to chronically engage the vessel wall once an optimal electrode location has been selected.

2011005, Mar 3, 2011

Oct 20, 2010

12/908086

Michael S. Williams - Santa Rosa CA, US
Terrance Ransbury - Chapel Hill NC, US
Richard A. Glenn - Santa Rosa CA, US
Kevin Holbrook - Chapel Hill NC, US

A61N 1/362, A61N 1/39

607 5, 607 9

The present application describes a retention device for anchoring a medical device within the vasculature. The device may include expandable member coupled to an intravascular medical device and proportioned for receipt within a vessel. At least a portion of the expandable member is expandable to radially engage a vessel wall and to thereby retain the medical device within the vessel. The system is suitable for a variety of intravascular devices, including but not limited to ICD's, pacemakers, and intravascular drug delivery systems.

2013015, Jun 13, 2013

Jun 28, 2012

13/536954

Michael S. Williams - Santa Rosa CA, US
Grant Williams - Larkspur CA, US
Richard A. Glenn - Santa Rosa CA, US

A61F 2/01

606200

An embolic deflection device includes an anchor engageable with a lumen of a branch vessel extending from an aortic arch and a deflection device, the deflection device having a first end coupled to the anchor and an elongate member extending from the deflection device. A method of deflecting embolic material away from a branch vessel extending from an aortic arch includes providing a deflection device comprising a anchor and an elongate member extending from the anchor. The anchor is engaged with a lumen of the branch vessel and positioned such that the elongate member extends within the aortic arch in proximity to ostia of at least two branch vessels. Embolic material flowing from the ascending aorta to the aortic arch is diverted by the elongate member away from the branch vessels and into the descending aorta.

2007002, Feb 1, 2007

Sep 30, 2006

11/541195

Michael Williams - Santa Rosa CA, US
Kevin Holbrook - Windsor CA, US

B29C 47/06

264173160, 264209300

Improved polymeric endoprostheses and methods of making endoprostheses are disclosed. Said endoprostheses exhibit improved overall compliance, selective regional compliance and selective radial strength without varying the geometries of selected regions. Numerous other physical characteristics of said endoprostheses may be selectively varied during manufacture. Some embodiments may comprise one or more erodible material. Some embodiments may comprise one or more therapeutics incorporated into said endoprosthesis via a solvent in a supercritical state.

2005023, Oct 20, 2005

Feb 10, 2005

11/055540

Michael Williams - Santa Rosa CA, US
Kevin Holbrook - Chapel Hill NC, US
Terrance Ransbury - Chapel Hill NC, US

A61K009/24, A61K009/22

604890100

Described herein is a system for intravascular drug delivery system, which includes a reservoir implantable a blood vessel, an intravascular pump fluidly coupled to the reservoir and an anchor expandable into contact with a wall of the blood vessel to retain the system within the vasculature. Delivery conduits may be extend from the reservoir and are positionable at select locations within the vasculature for target drug delivery to select organs or tissues.

7163554, Jan 16, 2007

Nov 8, 2004

10/984112

Michael S. Williams - Santa Rosa CA, US
Richard A. Glenn - Santa Rosa CA, US
Jeffrey A. Smith - Santa Rosa CA, US
Kevin D. Holbrook - Windsor CA, US
Joseph M. DeSimone - Chapel Hill NC, US

SyneCor, LLC - Durham NC

A61F 2/06

623 122, 623 116

A woven tubular endoprosthesis comprising means for locking the endoprosthesis in a deployed configuration is disclosed. The means for locking the endoprosthesis may comprise locking protrusions, notches, a chemical bond, a curable bond, or other mechanism. The woven fibers comprising the endoprosthesis may be hollow and comprise circumferentially oriented polymeric chains, and may be filled with a curable material. A method of treatment using an endoprosthesis according to the invention is also disclosed.

7082336, Jul 25, 2006

Jun 4, 2003

10/454223

Terrance Ransbury - Pleasanton CA, US
Michael S. Williams - Santa Rosa CA, US

Synecor, LLC - Durham NC

A61N 1/00

607126, 607 2, 607115, 607116

The present application describes an intravascular implantable pacing and/or defibrillation system. The described system includes a pulse generator that is implantable within a blood vessel and proportioned to blood flow through the blood vessel, and at least one lead attachable to the pulse generator. During implantation, the pulse generator is introduced into a patient's vasculature, advanced to a desired vessel and anchored in place within the vessel. The lead or leads are placed within the heart or surrounding vessels as needed to deliver electrical pulses to the appropriate location.

7529589, May 5, 2009

Jun 4, 2004

10/862113

Michael S. Williams - Santa Rosa CA, US
Terrance Ransbury - Chapel Hill NC, US
Richard A. Glenn - Santa Rosa CA, US
Daniel W. Fifer - Windsor CA, US
Kevin Holbrook - Cloverdale CA, US

Synecor LLC - Durham NC

A61N 1/05

607119, 607115, 607116

The present application describes an intravascular implantable pacing and/or defibrillation system. The described system includes a pulse generator that is implantable within a blood vessel and proportioned to blood flow through the blood vessel, and at least one electrode attachable to the pulse generator. During implantation, the pulse generator is introduced into a patient's vasculature, advanced to a desired vessel and anchored in place within the vessel. The electrode or electrodes are placed within the heart or surrounding vessels as needed to deliver electrical pulses to the appropriate location.

2005011, Jun 2, 2005

Nov 16, 2004

10/990158

Michael Williams - Santa Rosa CA, US
Jeffrey Smith - Santa Rosa CA, US
Kevin Holbrook - Chapel Hill CA, US

A61F002/44

623017160, 623017110

Devices and methods for manufacturing devices for treating degenerated and/or traumatized intervertebral discs are disclosed. Artificial discs and components of discs may include an artificial nucleus and/or an artificial annulus and may be comprised of shape memory materials synthesized to achieve desired mechanical and physical properties. An artificial nucleus and/or annulus according to the invention may comprise one or more hollow bodies that may be filled with a curable material for deployment. A hollow body according to the invention may comprise one or more partitions to define one or more chambers and may comprise means for directing the flow of material within said hollow body.