MICHAEL JOHN ZELESKO
Real Estate Commission in Hatboro, PA

6734194, May 11, 2004

Jun 18, 2003

10/464570

David William End - Ambler PA
Michael J. Zelesko - Hatboro PA

Janssen Pharmaceutica N.V.

A61K 3147

514312, 514154, 514 44

This invention comprises the use of compounds of formula (I) wherein the dotted line represents an optional bond; X is oxygen or sulfur; R is hydrogen, C alkyl, Ar , Ar C alkyl, quinolinylC alkyl, pyridylC alkyl, hydroxyC alkyl, C alkyloxyC alkyl, mono- or di(C alkyl)aminoC alkyl, aminoC alkyl, or a radical of formula —Alk —C( O)—R , —Alk —S(O)—R or —Alk —S(O) —R ; R , R and R each independently are hydrogen, hydroxy, halo, cyano, C alkyl, C alkyloxy, hydroxyC alkyloxy, C alkyloxy C alkyloxy, aminoC alkyloxy, mono- or di(C alkyl)aminoC alkyloxy, Ar , Ar C alkyl, Ar oxy, Ar C alkyloxy, hydroxycarbonyl, C alkyloxycarbonyl, trihalomethyl, trihalomethoxy, C alkenyl; R and R each independently are hydrogen, halo, Ar , C alkyl, hydroxyC alkyl, C alkyloxyC alkyl, C alkyloxy, C alkylthio, amino, hydroxycarbonyl, C alkyloxycarbonyl, C alkylS(O)C alkyl or C alkylS(O) C alkyl; R and R each independently are hydrogen, halo, cyano, C alkyl, 4,4-dimethyl-oxazolyl, C alkyloxy or Ar oxy; R is hydrogen, C alkyl, cyano, hydroxycarbonyl, C alkyloxycarbonyl, C alkylcarbonylC alkyl, cyanoC alkyl, C alkyloxycarbonylC alkyl, carboxyC alkyl, hydroxyC alkyl, aminoC alkyl, mono- or di(C alkyl)aminoC alkyl, imidazolyl, haloC alkyl, C alkyloxyC alkyl, aminocarbonylC alkyl, or a radical of formula —O—R , —S—R , —N—R R ; R is hydrogen, halo, cyano, C alkyl, C alkyloxycarbonyl, Ar ; R is hydrogen, C alkyl, C alkyloxy or halo; R is hydrogen or C alkyl; for the manufacture of a medicament to inhibit smooth muscle cell proliferation.

6743805, Jun 1, 2004

Nov 28, 2001

09/996147

David William End - Ambler PA
Michael J. Zelesko - Hatboro PA

Janssen Pharmaceutica NV - Beerse

A61K 3147

514312, 514154, 514 44

This invention comprises the use of compounds of formula (I) wherein the dotted line represents an optional bond; X is oxygen or sulfur; R is hydrogen, C alkyl, Ar , Ar C alkyl, quinolinylC alkyl, pyridylC alkyl, hydroxyC alkyl, C alkyloxyC alkyl, mono- or di(C alkyl)aminoC alkyl, aminoC alkyl, or a radical of formula -Alk -C( O)—R , -Alk -S(O)—R or -Alk -S(O) —R ; R , R and R each independently are hydrogen, hydroxy, halo, cyano, C alkyl, C alkyloxy, hydroxyC alkyloxy, C alkyloxyC alkyloxy, aminoC alkyloxy, mono- or di(C alkyl)aminoC alkyloxy, Ar , Ar C alkyl, Ar oxy, Ar C alkyloxy, hydroxycarbonyl, C alkyloxycarbonyl, trihalomethyl, trihalomethoxy, C alkenyl; R and R each independently are hydrogen, halo, Ar , C alkyl, hydroxyC alkyl, C alkyloxyC alkyl, C alkyloxy, C alkylthio, amino, hydroxycarbonyl, C alkyloxycarbonyl, C alkylS(O)C alkyl or C alkylS(O) C alkyl; R and R each independently are hydrogen, halo, cyano, C alkyl, 4,4-dimethyl-oxazolyl, C alkyloxy or Ar oxy; R is hydrogen, C alkyl, cyano, hydroxycarbonyl, C alkyloxycarbonyl, C alkylcarbonylC alkyl, cyanoC alkyl, C alkyloxycarbonylC alkyl, carboxyC alkyl, hydroxyC alkyl, aminoC alkyl, mono- or di(C alkyl)aminoC alkyl, imidazolyl, haloC alkyl, C alkyloxyC alkyl, aminocarbonylC alkyl, or a radical of formula —O—R , —S— R , —N—R R ; R is hydrogen, halo, cyano, C alkyl, C alkyloxycarbonyl, Ar ; R is hydrogen, C alkyl, C alkyloxy or halo; R is hydrogen or C alkyl; for the manufacture of a medicament to inhibit smooth muscle cell proliferation.

6365600, Apr 2, 2002

Nov 30, 1999

09/445009

David William End - Ambler PA
Michael J. Zelesko - Hatboro PA

Janssen Pharmaceutica, N.V.

A61K 3147

514312, 514154, 514 44

This invention comprises the use of compounds of formula (I) wherein the dotted line represents an optional bond; X is oxygen or sulfur; R is hydrogen, C alkyl, Ar , Ar C alkyl, quinolinylC alkyul, pyridylC alkyl, hydroxyC alkyl, C alkyloxyC alkyl, mono- or di(C alkyl)aminoC alkyl, aminoC alkyl, or a radical of formula —Alk —C(=))—R or —Alk —S(O) —R ; R , R and R each independently are hydrogen, hydroxy, halo, cyano, C alkyl, C alkyloxy, hydroxyC alkyloxy, C alkyloxyC alkyloxy, aminoC alkyloxy, mono- or di(C alkyl)aminoC alkyloxy, Ar Ar C alkyl, Ar -oxy, Ar C alkyloxy, hydroxycarbonyl, C alkyloxycarbonyl, trihalomethyl, trihalomethoxy, C alkenyl; R and R each independently are hydrogen, halo, Ar , C -alkyl, hydroxyC alkyl, C alkyloxyC alkyl, C alkyloxy, C alkylthio, amino, hydroxycarbony, C alkyloxycarbonyl, C alkylS(O)C alkul or C alkylS(O) C alkyl; R and R independenly are hydrogen, halo, cyano, C alkyl, 4,4-dimethyl-oxazolyl, C alkyloxy or Ar oxyl R is hydrogen, C alkyl, cyano, hydroxycarbonyl, C alkyloxycarbonyl, C alkylcarbonylC alkyl, cyanoC alkyl, C alkyloxycarbonylC alkyl, carboxyC alkyl, hydroxyC alkyl, aminoC alkyl, mono- or di(C alkyl)aminoC alkyl, imidazolyl, haloC alkyl, C alkyloxyC alkyl, aminocarbonylC alkyl, or a radical of formula —O—R , —S—R , —N—R R ; R is hydrogen, halo, cyano, C alkyl, C alkyloxycarbonyl, Ar ; R is hydrogen, C alkyl, C alkyloxy or halo; R is hydrogen or C alkyl; for the manufacture of a medicament to inhibit smooth muscle cell proliferation.

2004015, Aug 12, 2004

Jun 18, 2003

10/464702

David End - Ambler PA, US
Michael Zelesko - Hatboro PA, US

A61K031/4709

514/312000

This invention comprises the use of compounds of formula (I) wherein the dotted line represents an optional bond; X is oxygen or sulfur; Ris hydrogen, Calkyl, Ar, ArCalkyl, quinolinylCalkyl, pyridylCalkyl, hydroxyCalkyl, CalkyloxyCalkyl, mono- or di(Calkyl)aminoCalkyl, aminoCalkyl, or a radical of formula -Alk-C( O)—R, -Alk-S(O)—Ror -Alk-S(O)—R; R, Rand Reach independently are hydrogen, hydroxy, halo, cyano, Calkyl, Calkyloxy, hydroxyCalkyloxy, CalkyloxyCalkyloxy, aminoCalkyloxy, mono- or di(Calkyl)aminoCalkyloxy, Ar, ArCalkyl, Aroxy, ArCalkyloxy, hydroxycarbonyl, Calkyloxycarbonyl, trihalomethyl, trihalomethoxy, Calkenyl; Rand Reach independently are hydrogen, halo, Ar, Calkyl, hydroxyCalkyl, CalkyloxyCalkyl , Calkyloxy, Calkylthio, amino, hydroxycarbonyl, Calkyloxycarbonyl, CalkylS(O)Calkyl or CalkylS(O)Calkyl; Rand Reach independently are hydrogen, halo, cyano, Calkyl, 4,4-dimethyl-oxazolyl, Calkyloxy or Aroxy; Ris hydrogen, Calkyl, cyano, hydroxycarbonyl, Calkyloxycarbonyl, CalkylcarbonylCalkyl, cyanoCalkyl, CalkyloxycarbonylCalkyl, carboxyCalkyl, hydroxyCalkyl, aminoCalkyl, mono- or di(Calkyl)aminoCalkyl, imidazolyl, haloCalkyl, CalkyloxyCalkyl, aminocarbonylCalkyl, or a radical of formula —O—R, —S—R, —N—RR; Ris hydrogen, halo, cyano, Calkyl, Calkyloxycarbonyl, Ar; Ris hydrogen, Calkyl, Calkyloxy or halo; Ris hydrogen or Calkyl; for the manufacture of a medicament to inhibit smooth muscle cell proliferation.

7253183, Aug 7, 2007

Apr 14, 2004

10/823862

David William End - Ambler PA, US
Michael J. Zelesko - Hatboro PA, US

Janssen Pharmaceutica N.V. - Beerse

A61K 31/4709

514312, 514154

This invention comprises the use of compounds of formula (I).