Inventors:
SIMON W.M. JOHN - Bar Harbor ME, US
Michael Anderson - Iowa City IA, US
Rick Libby - Pittsford NY, US
Assignee:
The Jackson Laboratory - Bar Harbor ME
International Classification:
A61N 5/10
Abstract:
A method for treating, preventing and/or reducing neurodegeneration in subjects with neurodegenerative disease, such as those neurodegenerative diseases that affect the eye, including glaucoma, using radiation, such as gamma radiation or X-ray radiation, either alone or together with a bone marrow transfer treatment. The method includes irradiating a targeted area of an animal, such as the eye region, with radiation, either alone or followed by injection with T-cell depleted bone marrow cells. Also a method for screening and/or selecting agents and/or treatment methods for inhibiting, treating and/or reducing neurodegeneration, particularly the neurodegeneration of the eye that occurs as a consequence of glaucoma.