DR. MICHAEL JAY, RPH
Pharmacy in Lexington, KY
License number
Kentucky 011776
Category
Pharmacy
Type
Pharmacist
Address
Address
A262 University Of Kentucky, Lexington, KY 40536
Phone
(859) 218-6516
(859) 278-1093
(859) 278-1093
Personal information
See more information about MICHAEL JAY at radaris.comName
Address
Phone
3288 Nantucket Dr, Lexington, KY 40502
Professional information
See more information about MICHAEL JAY at trustoria.com
Ph-Sensitive Mucoadhesive Film-Forming Gels And Wax-Film Composites Suitable For Topical And Mucosal Delivery Of Molecules
Ph-Sensitive Mucoadhesive Film-Forming Gels And Wax-Film Composites Suitable For Topical And Mucosal Delivery Of Molecules
US Patent:
7803392, Sep 28, 2010
Filed:
Dec 27, 2000
Appl. No.:
09/748133
Inventors:
Russell Mumper - Lexington KY, US
Michael Jay - Lexington KY, US
Michael Jay - Lexington KY, US
Assignee:
University of Kentucky Research Foundation - Lexington KY
International Classification:
A61F 2/02
US Classification:
424423
Abstract:
The present invention relates to pH-sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules of interest, namely active pharmaceuticals. The gels comprise a pharmaceutically acceptable pH-sensitive polymer that responds to a lowering of pH by precipitating into films when in contact with the skin or mucosal surface. The films also comprise an adhesive polymer that allows the film to remain in contact with the tissue for an extended period of time. The wax-film composites comprise a bi-layer film having both the said pH-sensitive mucoadhesive layer to promote strong adherence to the skin and mucosal surfaces as well as a specially bonded wax layer intended to extend the adherence of the film to tissues for a prolonged period of time. The invention also relates to the use of said pH-sensitive film-forming gels and wax-film composites to deliver molecules of interest, such as small molecules, peptides, proteins, and nucleic acids either locally to act at the site of administration or for the absorption of said molecules of interest across biological membranes into the systemic circulation.
Biodegradable, Low Biological Toxicity Radiographic Contrast Medium And Method Of X-Ray Imaging
Biodegradable, Low Biological Toxicity Radiographic Contrast Medium And Method Of X-Ray Imaging
US Patent:
5019370, May 28, 1991
Filed:
Jul 10, 1989
Appl. No.:
7/377396
Inventors:
Michael J. Jay - Lexington KY
Assignee:
University of Kentucky Research Foundation - Lexington KY
International Classification:
A61K 4904, A61K 914, A61B 500
US Classification:
424 4
Abstract:
A biodegradable, low biological toxicity, particulate radiographic contrast medium comprises biodegradable polymeric spheres of average molecular weight average diameter about 10-1,000 nm or about 0. 01-1. 0 micron carrying in at least radiographic contrasting amount of a radiographically opaque element.
A method of obtaining a tomographic image of the body portion of a subject comprises administering to the subject a radiographically-detectable amount of the biodegradable, low-toxicity radiographic medium of claim 1; allowing for the spheres to be taken-up by the body portion; and X-raying an area comprising the body portion.
A method of improving the contrast of a tomographic image of a body portion of a subject comprises administering to the subject a radiographically-detectable amount of the biodegradable, low-toxicity radiographic medium of claim 1; allowing for the spheres to be selectively taken-up by the body portion; and X-raying an area comprising the body portion.
Ph-Sensitive Mucoadhesive Film-Forming Gels And Wax-Film Composites Suitable For Topical And Mucosal Delivery Of Molecules
Ph-Sensitive Mucoadhesive Film-Forming Gels And Wax-Film Composites Suitable For Topical And Mucosal Delivery Of Molecules
US Patent:
2002013, Sep 19, 2002
Filed:
Feb 7, 2002
Appl. No.:
10/072320
Inventors:
Russell Mumper - Lexington KY, US
Michael Jay - Lexington KY, US
Michael Jay - Lexington KY, US
Assignee:
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
International Classification:
A61K009/14
US Classification:
424/487000
Abstract:
The present invention relates to pH-sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules of interest, namely active pharmaceuticals. The gels comprise a pharmaceutically acceptable pH-sensitive polymer that responds to a lowering of pH by precipitating into films when in contact with the skin or mucosal surface. The films also comprise an adhesive polymer that allows the film to remain in contact with the tissue for an extended period of time. The wax-film composites comprise a bi-layer film having both the said pH-sensitive mucoadhesive layer to promote strong adherence to the skin and mucosal surfaces as well as a specially bonded wax layer intended to extend the adherence of the film to tissues for a prolonged period of time. The invention also relates to the use of said pH-sensitive film-forming gels and wax-film composites to deliver molecules of interest, such as small molecules, peptides, proteins, and nucleic acids either locally to act at the site of administration or for the absorption of said molecules of interest across biological membranes into the systemic circulation.
Formulations For Sustained-Release Of Topical Anesthetics And Methods Of Making And Using Same
Formulations For Sustained-Release Of Topical Anesthetics And Methods Of Making And Using Same
US Patent:
6074674, Jun 13, 2000
Filed:
Jul 20, 1998
Appl. No.:
9/119099
Inventors:
Michael Joseph Jay - Lexington KY
G. Thomas Kluemper - Lexington KY
Sang Hun Kim - Lexington KY
G. Thomas Kluemper - Lexington KY
Sang Hun Kim - Lexington KY
Assignee:
University of Kentucky Research Foundation - Lexington KY
International Classification:
A61K 950
US Classification:
424502
Abstract:
The present invention provides, inter alia, formulations useful to ameliorate symptoms associated with mucosal abrasions, specifically those due to dental orthodontic brackets; oral surgery; periodontal surgery or other procedures. For instance, there is a formulation comprising: 65 to 75% microcrystalline wax; 5 to 15% non-ionic polymer; 15 to 25% topical anesthetic; and 1 to 5% surfactant, wherein the ratio of non-ionic polymer to microcrystalline wax is no greater than 0. 2. Preferably, for solid topical anesthetics, the particle size is less than the apertures of a 100-mesh screen. However, the topical anesthetic may also be a liquid. Formulations wherein the mixture is a homogeneous matrix is preferred.
Microemulsions As Precursors To Solid Nanoparticles
Microemulsions As Precursors To Solid Nanoparticles
US Patent:
2007015, Jul 5, 2007
Filed:
Nov 9, 2006
Appl. No.:
11/558302
Inventors:
Russell Mumper - Lexington KY, US
Michael Jay - Lexington KY, US
Michael Jay - Lexington KY, US
International Classification:
C12Q 1/68, C12N 15/87, G01N 33/53
US Classification:
435006000, 435459000, 435007100, 977902000, 977924000
Abstract:
The preparation of novel microemulsions to be used as precursors for solid nanoparticles is described. The microemulsion precursors consist of either alcohol-in-fluorocarbon microemulsions, liquid hydrocarbon-in-fluorocarbon microemulsions, or liquid hydrocarbon-in-water microemulsions. The formed solid nanoparticles have diameters below 200 nanometers and can be made to entrap various materials including drugs, magnets, and sensors. The solid nanoparticles can be made to target different cells in the body by the inclusion of a cell-specific targeting ligand. Methods of preparing the novel microemulsion precursors and methods to cure solid nanoparticles are provided.
Nanoscintillation Systems For Aqueous-Based Liquid Scintillation Counting
Nanoscintillation Systems For Aqueous-Based Liquid Scintillation Counting
US Patent:
6855270, Feb 15, 2005
Filed:
Jun 6, 2002
Appl. No.:
10/165201
Inventors:
Russell J. Mumper - Lexington KY, US
Michael Jay - Lexington KY, US
Michael Jay - Lexington KY, US
Assignee:
The University of Kentucky Research Foundation - Lexington KY
International Classification:
C09K011/02
US Classification:
25230117, 250364, 250361 R, 2504831, 252646, 252644, 252645
Abstract:
The present invention relates to the use of nanoscintillation systems, or nanoparticles containing fluor molecules, that can be used to detect an electron-emitting or alpha-particle-emitting radioisotope in the absence of organic-solvents commonly used in organic-based liquid scintillation cocktails. The invention also relates to compositions and use of three oil-in-water microemulsion precursors that can be engineered rapidly, reproducibly, and cost-effectively to produce useful nanoparticles less than 100 nanometers.
Microemulsions As Precursors To Solid Nanoparticles
Microemulsions As Precursors To Solid Nanoparticles
US Patent:
7153525, Dec 26, 2006
Filed:
Mar 21, 2001
Appl. No.:
09/812884
Inventors:
Russell John Mumper - Lexington KY, US
Michael Jay - Lexington KY, US
Michael Jay - Lexington KY, US
Assignee:
The University of Kentucky Research Foundation - Lexington KY
International Classification:
A61K 9/14, B29B 9/00
US Classification:
424489, 424450, 424499, 514937, 514939, 264 5
Abstract:
The preparation of novel microemulsions to be used as precursors for solid nanoparticles is described. The microemulsion precursors consist of either alcohol-in-fluorocarbon microemulsions, liquid hydrocarbon-in-fluorocarbon microemulsions, or liquid hydrocarbon-in-water microemulsions. The formed solid nanoparticles have diameters below 200 nanometers and can be made to entrap various materials including drugs, magnets, and sensors. The solid nanoparticles can be made to target different cells in the body by the inclusion of a cell-specific targeting ligand. Methods of preparing the novel microemulsion precursors and methods to cure solid nanoparticles are provided.