MICHAEL J YASZEMSKI, M.D.
Medical Practice at 1 St, Rochester, MN

6384105, May 7, 2002

Apr 14, 2000

09/550372

Shulin He - Houston TX
Michael J. Yaszemski - Rochester MN
Antonios G. Mikos - Houston TX

William Marsh Rice University - Houston TX

C08F 828

523113, 523115, 525385, 525386

New injectable, in situ crosslinkable biodegradable polymer composites comprise poly(propylene fumarate) (PPF), poly(ethylene glycol)-dimethacrylate (PEG-DMA), an, optionally, -tricalcium phosphate (-TCP). A method for controlling the crosslinking characteristics of the composites, including the maximum crosslinking temperature and the gel point, as well as the properties of the cross linked composites such as the compressive strength and modulus and the water holding capacity, is disclosed.

2008026, Oct 23, 2008

Apr 28, 2006

11/912188

Shanfeng Wang - Knoxville TN, US
Lichun Lu - Rochester MN, US
Michael J. Yaszemski - Rochester MN, US

A61K 47/32, C08F 24/00, C08F 2/46, A61P 43/00, C12N 5/00, C08J 9/00

5147725, 526266, 522168, 521149, 435396

Improved methods for preparing polyethylene glycol fumarate) are disclosed. Methods for chemically crosslinking or photocross-linking hydrophilic polyethylene glycol fumarate) with hydrophobic polymers such as poly(propylene fumarate) (PPF) and poly(caprolactone fumarate) (PCLF) to form various hydrogels (FIG. ) with controllable hydrophilicity are also disclosed. The hydrogels are useful in the fabrication of injectable and in-situ hardening scaffolds for application in skeletal reconstruction. An injectable material including the hydrogels may be useful in controlled drug release.

2008020, Aug 28, 2008

Aug 27, 2004

10/568058

Esmaiel Jabbari - Rochester MN, US
Michael J. Yaszemski - Rochester MN, US
Bradford L. Currier - Rochester MN, US
Lichun Lu - Rochester MN, US

A61K 9/00, C08J 9/00, C08J 9/16, C08G 63/00, A61K 9/14, A61K 38/43, A61K 31/7052, A61P 43/00, A61K 38/02, A61K 38/16, A61K 38/14, A61K 39/395, A61K 31/70

424426, 521 50, 521 56, 521149, 521182, 424486, 424 941, 514 44, 514 2, 514 12, 514 8, 4241301, 514 23

Hydrogel microparticles with entrapped liquid are used as the porogen to reproducibly form interconnected pore networks in a porous scaffold. In one embodiment, a biodegradable unsaturated polymer, a crosslinking agent, and a porogen comprising biodegradable hydrogel microparticles are mixed together and allowed to form a porous scaffold in an mold or in a body cavity. Example biodegradable unsaturated polymers include poly(propylene fumarate) and poly(e-caprolactone-fumarate). The cosslinking agent may be a free radical initiator, or may include a free radical initiator and a monomer capable of addition polymerization. Example hydrogel microparticles include uncrosslinked or crosslinked collagen , an uncrosslinked or crosslinked collagen derivative, and an uncrosslinked or crosslinked synthetic biodegradable polymer such as oligo(poly(ethylene glycol) fumarate).

2010011, May 13, 2010

Jan 15, 2009

12/354142

Gobinda Sarkar - Rochester MN, US
Mark E. Bolander - Rochester MN, US
Deendayal Mandal - Kingston RI, US
Eric W. Mahlum - Rochester MN, US
Michael J. Yaszemski - Rochester MN, US

A61K 39/395, C07K 14/00, C07K 7/08, C07K 9/00, C07K 16/00, A61K 38/16, A61K 38/10, A61K 38/14, A61K 39/385, C12N 5/00, C12N 15/00, A61P 43/00

4241781, 530324, 530326, 530325, 530322, 5303911, 514 12, 514 13, 514 8, 4241931, 435375, 435440

Novel carrier peptides are described, as well as methods of using the carrier peptides to transport biologically active molecules into a cell, mitochondrion, or nucleus, e.g., by formation of a complex of the carrier peptide non-covalently bound to a biologically active molecule.

7163545, Jan 16, 2007

Jul 29, 2003

10/629427

Michael J. Yaszemski - Rochester MN, US
Jonathan A. Friedman - Rochester MN, US
Michael J. Moore - Rochester MN, US
Anthony J. Windebank - Rochester MN, US

Mayo Foundation for Medical Education and Research - Rochester MN

A61B 17/08

606152, 606153, 606154, 606155, 424423, 424426

An implant for bridging a gap in a severed spinal cord or nerve and for promoting nerve regeneration has a matrix comprising a biocompatible, biodegradable, polymeric material. The matrix has a proximal end for connection to a first end of severed spinal cord and a distal end for connection to a second end of severed spinal cord. The matrix includes internal guidance channels extending between the proximal end and the distal end to facilitate rejoining of the first end and the second end of the severed spinal cord. A bioactive agent may be dispersed in the matrix, or disposed in the channels, or included within microspheres in the channels. The channels may be arranged such that guidance channels correspond to spinal cord tracts. Alternatively, guidance channels may be spaced apart at the proximal end of the matrix and converge inward toward the axis of the matrix at the distal end.

7642300, Jan 5, 2010

Jun 29, 2004

10/562591

Michael J. Yaszemski - Rochester MN, US
Bradford L. Currier - Rochester MN, US
Esmaiel Jabbari - Columbia SC, US
Lichun Lu - Rochester MN, US

C08F 297/02, C08F 297/00

523113, 523114, 523115, 523116, 424424

A composition is disclosed which comprises (i) a macromer prepared by reacting an unsaturated diacid having a carbon-carbon double bond and a saturated diacid, and (ii) a bioactive ceramic grafted to the macromer. In one embodiment, the unsaturated diacid having a carbon-carbon double bond is fumaric acid, the saturated diacid is compatible with fumaric acid and poly(propylene fumarate) such as succinic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid and mixtures thereof, and the bioactive ceramic is hydroxyapatite. In another embodiment, hydroxyapatite is grafted with a biodegradable and crosslinkable macromer comprising silane units alternating with furnarate and adipate units.

2008019, Aug 14, 2008

Nov 10, 2005

11/718906

Shangfeng Wang - Rochester MN, US
Lichun Lu - Rochester MN, US
Michael Yaszemski - Rochester MN, US

C08G 63/02, C08G 63/13, C08L 67/02, B32B 27/36

528275000, 528272000, 528274000

Fumaric acid or a salt thereof, such as a fumaryl halide (e.g. fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with poly(caprolactone) diol in the presence of an alkali metal salt. The resulting photocrosslinkable biocompatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable an in-situ hardening scaffolds for application in skeletal reconstruction.

2009005, Feb 26, 2009

Jun 9, 2005

11/628996

Kenton R. Kaufman - Rochester MN, US
Michael J. Yaszemski - Rochester MN, US

MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH - Rochester MN

A61F 5/00

602 19, 602 13, 602 16

A thoracolumbosacral and a lumbosacral orthosis with sagittal-coronal control are disclosed. The orthoses have two rigid anterior and posterior plastic shells. The anterior shell extends from the pelvis to the sternum. The posterior shell extends from the pelvis and terminates just inferior to the scapular spine. An interior surface of the anterior shell has pressure pads that apply pressure to locations on the patient's anterior torso and the interior surface of the posterior shell has pressure pads that apply pressure to locations on the patient's posterior torso when the anterior shell and the posterior shell are secured to the patient's torso. The pressure pads may be inflatable air bladders.