Inventors:
Arthur Gertzman - Flemington NJ, US
Michael Kawas - Freehold NJ, US
Katherine G. Truncale - Hillborough NJ, US
Moon Hae Sunwoo - Old Tappan NJ, US
Alison Lee - Piscataway NJ, US
Richard Seeman - South Bound Brook NJ, US
Carl Alexander DePaula - Malvern PA, US
Jeffrey S. Cartmell - Freehold NJ, US
David J. Gocke - Princeton NJ, US
Carina Syring - Biel-Benken, CH
Rudiger von Versen - Wanditz, DE
International Classification:
A01N 1/02, C12N 5/071, A01N 1/00
Abstract:
In certain embodiments, the present invention relates to a process for preparing skin removed from a human donor, including a living human donor, and removing cellular components and forming a decellular matrix having as major components collagens and elastins while disinfecting the tissue. In other embodiments, the present invention relates to a process for treating a decellularized soft tissue by freezing the same at a plurality of decreasing temperatures at atmosphere or higher such that there is formation of ice crystals having a size greater than 2.0 and lyophilizing the soft tissue under vacuum to remove the water to less than 6% forming a porous matrix.