Inventors:
- Wiesbaden, DE
Richard J. Gorczynski - Westminister CO, US
Michael J. Gerber - Denver CO, US
International Classification:
A61K 31/4025, A61K 45/06
US Classification:
514 154, 514422, 51421207, 514221, 514392, 514307, 51421105, 514412, 514409, 51421103, 514381, 514397, 514382, 514394, 5142235, 514417, 51426631, 514415, 5142663, 514346
Abstract:
A method for enhancing glycemic control and/or insulin sensitivity in a human subject having diabetic nephropathy and/or metabolic syndrome comprises administering to the subject a selective endothelin A (ET) receptor antagonist in a glycemic control and/or insulin sensitivity enhancing effective amount. A method for treating a complex of comorbidities in an elderly diabetic human subject comprises administering to the subject a selective ETreceptor antagonist in combination or as adjunctive therapy with at least one additional agent that is (i) other than a selective ETreceptor antagonist and (ii) effective in treatment of diabetes and/or at least one of said comorbidities other than hypertension. A therapeutic combination useful in such a method comprises a selective ETreceptor antagonist and at least one antidiabetic, anti-obesity or antidyslipidemic agent other than a selective ETreceptor antagonist.