MICHAEL GILBERT GOGGINS, M.D.
Osteopathic Medicine at Wolfe St, Baltimore, MD
License number
Maryland D57607
Category
Osteopathic Medicine
Type
Gastroenterology
Address
Address
600 N Wolfe St, Baltimore, MD 21287
Phone
(410) 955-4166
Personal information
See more information about MICHAEL GILBERT GOGGINS at radaris.comName
Address
Phone
6809 Newstead Ln, Baltimore, MD 21209
4446 Roland Spring Dr, Baltimore, MD 21210
605 Stoney Spring Dr, Baltimore, MD 21210
Baltimore, MD
Professional information
Pathways Underlying Pancreatic Tumorigenesis And An Hereditary Pancreatic Cancer Gene
US Patent:
2012011, May 10, 2012
Filed:
Sep 3, 2009
Appl. No.:
13/060453
Inventors:
Bert Vogelstein - Baltimore MD, US
Kenneth W. Kinzler - Baltimore MD, US
D. Williams Parsons - Ellicott City MD, US
Sian Jones - Baltimore MD, US
Xiaosong Zhang - Baltimore MD, US
Jimmy Cheng-Ho Lin - Baltimore MD, US
Rebecca J. Leary - Baltimore MD, US
Philipp Angenendt - Hamburg, DE
Nickolas Papadopoulos - Towson MD, US
Victor Velculescu - Dayton MD, US
Giovanni Parmigiani - Brookline MA, US
Rachel Karchin - Towson MD, US
Scott Kern - Hunt Valley MD, US
Ralph Hruban - Baltimore MD, US
James R. Eshleman - Lutherville MD, US
Michael Goggins - Baltimore MD, US
Alison Klein - Baltimore MD, US
Kenneth W. Kinzler - Baltimore MD, US
D. Williams Parsons - Ellicott City MD, US
Sian Jones - Baltimore MD, US
Xiaosong Zhang - Baltimore MD, US
Jimmy Cheng-Ho Lin - Baltimore MD, US
Rebecca J. Leary - Baltimore MD, US
Philipp Angenendt - Hamburg, DE
Nickolas Papadopoulos - Towson MD, US
Victor Velculescu - Dayton MD, US
Giovanni Parmigiani - Brookline MA, US
Rachel Karchin - Towson MD, US
Scott Kern - Hunt Valley MD, US
Ralph Hruban - Baltimore MD, US
James R. Eshleman - Lutherville MD, US
Michael Goggins - Baltimore MD, US
Alison Klein - Baltimore MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
C12Q 1/68, C40B 20/00, C07H 21/04
US Classification:
506 2, 435 611, 536 2431, 536 2433
Abstract:
There are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a comprehensive analysis of the genes altered in 24 pancreatic tumors. First, we determined the sequences of 23,781 transcripts, representing 20,583 protein-encoding genes, in DNA from these tumors. Second, we searched for homozygous deletions and amplifications using microarrays querying ˜one million single nucleotide polymorphisms in each sample. Third, we analyzed the transcriptomes of the same samples using SAGE and next-generation sequencing-by-synthesis technologies. We found that pancreatic cancers contain an average of 63 genetic alterations, of which 49 are point mutations, 8 are homozygous deletions, and 6 are amplifications. Further analyses revealed a core set of 12 regulatory processes or pathways that were each genetically altered in 70% to 100% of the samples. The data suggest that dysregulation of this core set of pathways is responsible for the major features of pancreatic tumorigenesis.
Differentially Methylated Sequences In Pancreatic Cancer
US Patent:
2005006, Mar 31, 2005
Filed:
Jul 8, 2004
Appl. No.:
10/889898
Inventors:
Michael Goggins - Baltimore MD, US
Takashi Ueki - Sparks MD, US
Takashi Ueki - Sparks MD, US
International Classification:
C12Q001/68, C07H021/04, C07K014/47, C12N009/22
US Classification:
435006000, 435069100, 435199000, 435320100, 435325000, 536023200
Abstract:
The present invention provides a method for detecting a cellular proliferative disorder in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having said cellular proliferative, thereby detecting a cellular proliferative disorder in the subject.
Differentially Methylated Sequences In Pancreatic Cancer
US Patent:
2003019, Oct 9, 2003
Filed:
Feb 25, 2002
Appl. No.:
10/084555
Inventors:
Michael Goggins - Baltimore MD, US
Takashi Ueki - Sparks MD, US
Takashi Ueki - Sparks MD, US
International Classification:
C12Q001/68, C07H021/04, C12P019/34, C12N009/22, C12N009/10
US Classification:
435/006000, 435/091200, 435/199000, 536/023200, 435/193000
Abstract:
The present invention provides a method for detecting a cellular proliferative disorder in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having said cellular proliferative, thereby detecting a cellular proliferative disorder in the subject.
Aberrantly Methylated Genes In Pancreatic Cancer
US Patent:
7485418, Feb 3, 2009
Filed:
Mar 17, 2004
Appl. No.:
10/548976
Inventors:
Michael G. Goggins - Baltimore MD, US
Norihiro Sato - Baltimore MD, US
Norihiro Sato - Baltimore MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
C12Q 1/68, C12P 19/34
US Classification:
435 6, 435 912
Abstract:
The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant methylation of regions of the gene or regulatory region, wherein aberrant methylation is identified as being different when compared to the same regions of the gene or associated regulatory region in a subject not having the pancreatic carcinoma, thereby detecting pancreatic carcinoma in the subject.
Professor At Jhu
Position:
Professor at JHU
Location:
Baltimore, Maryland Area
Industry:
Medical Practice
Work:
JHU
-
Professor
Michael Gilbert Goggins, Baltimore MD
Specialties:
Internal Medicine, Gastroenterology, Diagnostic Radiology
Work:
The Johns Hopkins Hospital
600 N Wolfe St, Baltimore, MD 21287 John Hopkins Medicine
10755 Falls Rd, Lutherville Timonium, MD 21093 Johns Hopkins Womens Center
601 N Caroline St, Lutherville Timonium, MD 21093 John Hopkins Medicine
2360 W Joppa Rd, Lutherville Timonium, MD 21093 John Hopkins Medicine
601 N Caroline St, Baltimore, MD 21287
600 N Wolfe St, Baltimore, MD 21287 John Hopkins Medicine
10755 Falls Rd, Lutherville Timonium, MD 21093 Johns Hopkins Womens Center
601 N Caroline St, Lutherville Timonium, MD 21093 John Hopkins Medicine
2360 W Joppa Rd, Lutherville Timonium, MD 21093 John Hopkins Medicine
601 N Caroline St, Baltimore, MD 21287
Education:
Trinity College, University Of Dublin (1988)
Dr. Michael G Goggins, Baltimore MD - MD (Doctor of Medicine)
Specialties:
Gastroenterology
Address:
JOHNS HOPKINS HOSPITAL
600 N Wolfe St, Baltimore 21287
(410) 955-5080 (Phone), (410) 955-1464 (Fax)
Gastroenterology Pathology
1550 Orleans St SUITE 341, Baltimore 21287
(410) 955-3511 (Phone)
600 N Wolfe St, Baltimore 21287
(410) 955-5080 (Phone), (410) 955-1464 (Fax)
Gastroenterology Pathology
1550 Orleans St SUITE 341, Baltimore 21287
(410) 955-3511 (Phone)
Languages:
English
Hospitals:
JOHNS HOPKINS HOSPITAL
600 N Wolfe St, Baltimore 21287
Gastroenterology Pathology
1550 Orleans St SUITE 341, Baltimore 21287
The Johns Hopkins Hospital
1800 Orleans St, Baltimore 21287
600 N Wolfe St, Baltimore 21287
Gastroenterology Pathology
1550 Orleans St SUITE 341, Baltimore 21287
The Johns Hopkins Hospital
1800 Orleans St, Baltimore 21287
Education:
Medical School
School Of Physic Trinity College University Of Dublin
School Of Physic Trinity College University Of Dublin
Michael Gilbert Goggins, Baltimore MD
Specialties:
Gastroenterologist
Address:
600 N Wolfe St, Baltimore, MD 21287
1550 Orleans St, Baltimore, MD 21287
601 N Caroline St, Baltimore, MD 21287
1550 Orleans St, Baltimore, MD 21287
601 N Caroline St, Baltimore, MD 21287
Methylated Gene Biomarkers For Detecting Cancer
US Patent:
7879542, Feb 1, 2011
Filed:
Aug 2, 2006
Appl. No.:
10/561877
Inventors:
Michael G. Goggins - Baltimore MD, US
Sato Norihiro - Fukuoka, JP
Sato Norihiro - Fukuoka, JP
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
C12Q 1/68, C07H 21/00, C07H 21/02, C07H 21/04
US Classification:
435 6, 536 221, 536 231, 536 243
Abstract:
The present invention includes methods diagnosising of cancer by analysis of a patient sample, particularly for the presence of a methylated SPARC nucleic acid molecule, and particularly for the diagnosis of pancreatic cancer. The invention also includes therapeutic methods for treating cancers by administering to cancers patients therapeutically effective amounts of demethylating agents.
Diagnostic Method Using Palb2
US Patent:
2012003, Feb 9, 2012
Filed:
Mar 5, 2010
Appl. No.:
13/254610
Inventors:
Bert Vogelstein - Baltimore MD, US
Kenneth W. Kinzler - Baltimore MD, US
D. Williams Parsons - Ellicott City MD, US
Sian Jones - Baltimore MD, US
Scott Kern - Hunt Valley MD, US
Ralph Hruban - Baltimore MD, US
James R. Eshleman - Lutherville MD, US
Michael Goggins - Baltimore MD, US
Alison Klein - Baltimore MD, US
Manuel Hidalgo - Baltimore MD, US
Victor E. Velculescu - Dayton MD, US
Kenneth W. Kinzler - Baltimore MD, US
D. Williams Parsons - Ellicott City MD, US
Sian Jones - Baltimore MD, US
Scott Kern - Hunt Valley MD, US
Ralph Hruban - Baltimore MD, US
James R. Eshleman - Lutherville MD, US
Michael Goggins - Baltimore MD, US
Alison Klein - Baltimore MD, US
Manuel Hidalgo - Baltimore MD, US
Victor E. Velculescu - Dayton MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
A61K 33/24, A61P 35/00, C40B 20/08, G01N 33/577, G01N 33/566, C12Q 1/68
US Classification:
424649, 435 723, 435 612, 435 611, 506 6
Abstract:
The present invention provides a method for detecting mutations in the PALB2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a PALB2 mutation or abberant PALB2 gene expression in a patient.