DR. MICHAEL G. ROSENFELD, M.D.
Medical Practice in San Diego, CA

6812336, Nov 2, 2004

May 5, 2000

09/445353

Michael G. Rosenfeld - San Diego CA
Christopher K. Glass - San Diego CA
David W. Rose - San Diego CA
Joseph Torchia - London, CA

The Regents of the University of California - Oakland CA

C07H 2104

536 235, 530350

The present invention provides a substantially purified nucleic acid molecule encoding p/CIP, which regulates the activity of CBP/p300 dependent transcription factors. The invention also provides substantially purified p/CIP and peptide portions of p/CIP. The invention also provides methods of selectively inhibiting signal transduction pathways using a peptide portion of p/CIP or a nucleic acid molecule encoding such a peptide portion.

5612220, Mar 18, 1997

Dec 1, 1994

8/347826

Bogi Andersen - La Jolla CA
Richard V. Pearse - San Diego CA
Peter N. Schlegel - New York NY
Michael G. Rosenfeld - San Diego CA
C. Wayne Bardin - New York NY

The Population Council, Center for Biomedical Research - New York NY

C12N 100, C12N 510, C12N 1511, C12N 1563

4353201

Disclosed is a POU transcription factor, Sprm-1 and analogs thereof, DNA molecules encoding the Sprm-1 proteins, and chimeric constructs, vectors and host cells containing the DNA molecules. Also disclosed are methods to identify putative male contraceptive agents. One involves the steps of isolating a DNA regulatory region responsive to Sprm-1, stably transforming a heterologous cell line with a first chimeric DNA construct containing a constitutive promoter capable of functioning in the cell line operably linked to a Sprm-1 DNA and a second chimeric DNA construct containing the DNA regulatory region operably linked to a reporter gene. The thus-transformed cell line is cultural in media containing the compound so that the thus-cultured cell line can be assayed to determine the Sprm-1 inhibitory activity of the compound. The above method can be modified to evaluate the Sprm-1 inhibitory activity of DNA molecules of interest, by transiently transfecting the thus-transformed cell line with a third DNA construct containing a constitutive promoter capable of functioning in the cell line operably linked to the DNA molecule, and then culturing the thus-transfected cell line so that it can be assayed to determine the inhibitory activity of the DNA molecule. Antibodies specific to Sprm-1, and their use in diagnosing male germ cell Sprm-1-mediated diseases or conditions are further disclosed.

5484732, Jan 16, 1996

Mar 22, 1993

8/035392

Michael G. Rosenfeld - San Diego CA
Bogi Anderson - La Jolla CA

The Regents of the University of California - Oakland CA

C12N 1511, C12N 1512, C12N 1563, C07K 1400

4353201

A gene encoding for alternative forms of a POU domain transcription factor is disclosed. The first polypeptide form of the transcription factor includes a transferable region which inhibits DNA binding by itself and other transcription factors. The second polypeptide form serves to activate expression of a gene typical for terminal differentiation of skin. Fusion proteins wherein the inhibitory region of the first form of the gene is coupled to, and inhibits the function of, other transcription factors are also disclosed.

7211402, May 1, 2007

Oct 21, 2004

10/971982

Michael G. Rosenfeld - San Diego CA, US
Christopher K. Glass - San Diego CA, US
David W. Rose - San Diego CA, US
Joseph Torchia - London, CA

The Regents of the University of California - Oakland CA

G01N 33/53, C07K 14/47

435 71, 550350

The present invention provides a substantially purified nucleic acid molecule encoding a p/CIP polypeptide, which regulates the activity of CBP/p300-dependent transcription factors. The invention also provides a substantially purified p-CIP polypeptide and active fragments thereof. In addition, the invention provides methods of identifying an effective agent that alters the association of a p/CIP polypeptide with a second protein. Further provided herein are methods of selectively inhibiting signal transduction pathways using an active fragment of a p/CIP polypeptide or a nucleic acid molecule encoding such an acive fragment.

7625874, Dec 1, 2009

Apr 11, 2007

11/734267

Sylvia Evans - Del Mar CA, US
Ju Chen - San Diego CA, US
Chenleng Cai - San Diego CA, US
Wenlai Zhou - San Diego CA, US
Michael G Rosenfeld - San Diego CA, US

The Regents of the University of California - Oakland CA

A61K 48/00, C07H 21/02, C07H 21/04, C12N 15/63

514 44, 536 231, 536 245, 4353201

The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.

4736023, Apr 5, 1988

Mar 4, 1985

6/707946

Ronald M. Evans - La Jolla CA
Michael G. Rosenfeld - San Diego CA

The Salk Institute for Biological Studies - San Diego CA

C07H 1512

536 27

Human CGRP (calcitonin-gene-related peptide) has the formula: H-Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg- Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe -NH. sub. 2. Human CGRP or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to influence memory, mood and pain appreciation and to achieve a substantial lowering of blood pressure or gastric acid secretion over an extended period of time. They also may be administered to affect ingestion behavior, taste and sensory perception. By using human CGRP to generate production of antibodies, it should be possible to diagnose human medullary thyroid carcinoma via immunoassay techniques.

7981615, Jul 19, 2011

Nov 2, 2009

12/611047

Sylvia Evans - Del Mar CA, US
Ju Chen - San Diego CA, US
Chenleng Cai - San Diego CA, US
Wenlai Zhou - San Diego CA, US
Michael G. Rosenfeld - San Diego CA, US

The Regents of the University of California - Oakland CA

C12Q 1/68, C07H 21/02, C07H 21/04, C07K 16/00

435 6, 536 231, 536 245, 5303871

The invention herein provides a mode of treating a disease associated with the regulation of T-Box and N-Myc gene, which includes cancers and heart disease in human and other subjects by identifying and administering a compound which modulates T-Box or N-Myc function. The invention also provides polynucleotides, polypeptides, vectors, cells, tissues and organisms useful in the identification and treatment of metabolic syndrome. A number of desirable cell proliferation and senescence regulating aspects are achieved by various embodiments of the present invention.

2011004, Feb 24, 2011

Nov 14, 2007

12/514952

Xiang-Dong Fu - San Diego CA, US
Michael G. Rosenfeld - San Diego CA, US

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

C12Q 1/68

435 6

The disclosure provides methods and compositions useful for high throughput sequencing of nucleic acid sequences associated with gene expression, nucleic acid-polypeptide interactions, and/or chromosomal interactions.

4549986, Oct 29, 1985

Dec 23, 1983

6/565035

Ronald M. Evans - La Jolla CA
Michael G. Rosenfeld - San Diego CA

The Salk Institute for Biological Studies - San Diego CA

C07C10352

2601125T

Human CGRP (calcitonin-gene-related peptide) has the formula: H-Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg- Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe -NH. sub. 2. Human CGRP or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to influence memory, mood and pain appreciation and to achieve a substantial lowering of blood pressure or gastric acid secretion over an extended period of time. They also may be administered to affect ingestion behavior, taste and sensory perception. By using human CGRP to generate production of antibodies, it should be possible to diagnose human medullary thyroid carcinoma via immunoassay techniques.

4737578, Apr 12, 1988

Apr 7, 1986

6/848924

Ronald M. Evans - San Diego CA
Michael G. Rosenfeld - San Diego CA
Gail Cerelli - Cardiff CA
Kelly E. Mayo - Wilmette IL
Joachim Spiess - Encinitas CA
Jean E. F. Rivier - La Jolla CA
Wylie W. Vale - La Jolla CA

The Salk Institute for Biological Studies - San Diego CA

C07K 710, C07K 1300

530350

Proteins with inhibin activity having a weight of about 32,000 daltons. The molecule is composed of two chains having molecular weights of about 18,000 and about 14,000 daltons, respectively, which are bound together by disulfide bonding. The 18K chain is obtained from the human inhibin gene and has the formula: H-Ser-Thr-Pro-Leu-Met-Ser-Trp-Pro-Trp-Ser-Pro-Ser-Ala-Leu-Arg-Leu-Leu-Gln- Arg-Pro-Pro-Glu-Glu-Pro-Ala-Ala-His-Ala-Asn-Cys-His-Arg-Val-Ala-Leu-Asn-Ile -Ser-Phe-Gln-Glu-Leu-Gly-Trp-Glu-Arg-Trp-Ile-Val-Tyr-Pro-Pro-Ser-Phe-R. sub. 65 -Phe-His-Tyr-Cys-His-Gly-Gly-Cys-Gly-Leu-His-Ile-Pro-Pro-Asn-Leu-Ser-Leu-P ro-Val-Pro-Gly-Ala-Pro-Pro-Thr-Pro-Ala-Gln-Pro-Tyr-Ser-Leu-Leu-Pro-Gly-Ala- Gln-Pro-Cys-Cys-Ala-Ala-Leu-Pro-Gly-Thr-Met-Arg-Pro-Leu-His-Val-Arg-Thr-Thr -Ser-Asp-Gly-Gly-Tyr-Ser-P e-Lys-Tyr-Glu-Thr-Val-Pro-Asn-Leu-Leu-Thr-Gln-His-Cys-Ala-Cys-Ile-OH, wherein R. sub. 65 is Ile or Arg. The 18K chain is connected by disulfide bonding to the 14K chain.