Inventors:
Jeffrey L. Cleland - San Carlos CA, US
Amy Lim - San Bruno CA, US
Michael Frank Powell - San Francisco CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K051/00, A61K039/00, A61K039/38, A61K009/22, A61M036/14
US Classification:
424468, 424 111, 424 117, 424 129, 424 153, 424 157, 4241841, 4242781, 424400, 424408, 424417, 424418, 424420, 424425, 424428, 424450, 424469, 424472, 424490, 424491
Abstract:
Methods and compositions are provided for the encapsulation of antigens in PLGA microspheres for use as vaccines. Such microspheres can also contain adjuvants. Mixtures of microspheres are provided which release antigen at desired intervals to provide boosts with antigen.