Inventors:
Julian Adams - Boston MA, US
Alfredo C. Castro - Winchester MA, US
Michael A. Foley - Chestnut Hill MA, US
Somarajan Nair Janardanan Nair - Belmont MA, US
Marta Nevalainen - Quincy MA, US
James R. Porter - Brighton MA, US
Martin R. Tremblay - Melrose MA, US
Assignee:
Infinity Discovery, Inc. - Cambridge MA
International Classification:
A61K 31/438, A61K 31/4355, C07D 491/10, C07D 491/048
Abstract:
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.