Inventors:
Patrick G. Harran - Los Angeles CA, US
Michael S. Brown - Dallas TX, US
Joseph L. Goldstein - Dallas TX, US
Jin Yang - Dallas TX, US
International Classification:
C12N 9/99, C07D 233/56, C07D 239/26, C07D 207/273, C07D 235/12, C07C 313/20, C07D 263/32, C07C 271/44, C07D 291/00
US Classification:
435184, 560132, 5483415, 544335, 544 2, 5483101, 564102, 548235, 548550
Abstract:
Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition.