MICHAEL E PICHICHERO, MD
Osteopathic Medicine at Clinton Ave, Rochester, NY

2001000, Jul 19, 2001

Feb 15, 2001

09/784480

Mitchell Auran - Boca Raton FL, US
Steven Stull - Boynton Beach FL, US
Michael Pichichero - Rochester NY, US

G09B023/28

434/270000

A device for training physicians in tympanocentesis is disclosed. The device includes an outer member resembling a side profile of a child's head and shoulder's area. The outer member is attached to a surface portion to define a receiving area for receiving a slidable inner member. A replica of at least an eardrum and ear canal of a child's inner ear is associated with the sliding inner member. A training portion of the inner member supports a simulated inner ear, positions the simulated inner ear to a desired position adjacent the outer ear of the outer member, and acts as a holder for the training cartridges used with the training device. The cartridges simulate the “look and feel” of popping through the tympanic membrane. The cartridges include one or more training areas. Two color distinct training materials are maintained within each training area of the top member of the cartridge. The first training material represents a desired safe puncture area for performing tympanocentesis. A third training material can be disposed within the training areas of a bottom member of the cartridge. If the first training material has been withdrawn the user has successfully positioned the needle into the correct area of the simulated ear, evidencing a proper tympanocentesis procedure. If the second training material has been withdrawn the user has punctured an undesired area. Regardless of whether the first or second training material was initially punctured, if the third training material is withdrawn the user has over punctured the area. Thus, the present invention trains the user in proper location and depth. Once all of the training areas of the cartridge have been used, it is replaced with a new cartridge.

6241526, Jun 5, 2001

Jan 14, 2000

9/483732

Mitchell Auran - Boca Raton FL
Steven Stull - Boynton Beach FL
Michael Pichichero - Rochester NY

Outcomes Management Educational Workshops, Inc. - Boynton Beach FL

G09B 2328

434270

A device for training physicians in tympanocentesis is disclosed. The device includes an outer member resembling a side profile of a child's head and shoulder's area. The outer member is attached to a surface portion to define a receiving area for receiving a slidable inner member. A replica of at least an eardrum and ear canal of a child's inner ear is associated with the sliding inner member. A training portion of the inner member supports a simulated inner ear, positions the simulated inner ear to a desired position adjacent the outer ear of the outer member, and acts as a holder for the training cartridges used with the training device. The cartridges simulate the "look and feel" of popping through the tympanic membrane. The cartridges include one or more training areas. Two color distinct training materials are maintained within each training area of the top member of the cartridge.

2012000, Jan 5, 2012

Aug 8, 2008

12/672604

Mingtao Zeng - Pittsford NY, US
Michael E. Pichichero - Rochester NY, US
Qingfu Xu - Rochester NY, US

UNIVERSITY OF ROCHESTER - Rochester NY

A61K 39/395, C12N 15/62, C12N 15/63, A61P 37/04, C07K 19/00, A61K 39/08, C07K 16/12, A61P 31/04, C12N 15/31, C12N 5/10

4241671, 536 237, 536 234, 4353201, 435325, 530350, 4242391, 4241921, 5303895

The invention relates to novel DNA and protein vaccines against . The DNA vaccine includes a DNA molecule that includes a first segment encoding a fragment of a heavy chain region of a neurotoxin, wherein the first segment is codon-enhanced to improve expression of the isolated DNA molecule in a mammalian host, and preferably a second segment that encodes a secretion signal peptide. The chimeric protein of the present invention includes the secretion signal peptide linked N-terminal of the fragment of a heavy chain region of a neurotoxin. Use of these materials to raise antibodies, and to impart resistance against to a mammal is also disclosed.

2013000, Jan 3, 2013

Jun 4, 2012

13/488293

Michael Pichichero - Rochester NY, US
Kyle Liu - Rochester NY, US

G01N 33/566, A61P 31/04, A61K 35/00, C40B 30/04, C12Q 1/68

514789, 435 794, 506 9, 435 612, 435 611, 435 792

Compositions and methods related to diagnosis of ear infections and acute otitis media.

2013015, Jun 20, 2013

Jun 4, 2012

13/488251

MICHAEL PICHICHERO - ROCHESTER NY, US
M. NADEEM KHAN - ROCHESTER NY, US
RAVINDER KAUR - PITTSFORD NY, US
SHARAD SHARMA - ROCHESTER NY, US
JANET CASEY - PITTSFORD NY, US
LEA MICHEL - ROCHESTER NY, US

A61K 39/102, G01N 33/68

4241901, 530300, 4242561, 435188, 435 792

Disclosed are compositions and methods related to vaccination for AOM and children prone to AOM.