Michael E. Bouchard
Architects at Massachusetts Ave, Cambridge, MA
License number
North Carolina 12120
Category
Architecture
Address
Address
1000 Massachusetts Ave, Cambridge, MA 02138
Professional information
Articles Having Non-Fouling Surfaces And Processes For Preparing The Same Without Altering Bulk Physical Properties
US Patent:
8574660, Nov 5, 2013
Filed:
Jun 9, 2011
Appl. No.:
13/156904
Inventors:
Douglas J. K. Weaver - Cambridge MA, US
Jun Li - Cambridge MA, US
Zheng Zhang - Cambridge MA, US
Abby N. Deleault - Cambridge MA, US
Eric W. Marchese - Cambridge MA, US
Phu C. Nguyen - Cambridge MA, US
Chad C. Huval - Cambridge MA, US
Michael A. Bouchard - Cambridge MA, US
Arthur J. Coury - Cambridge MA, US
Christopher R. Loose - Cambridge MA, US
Jun Li - Cambridge MA, US
Zheng Zhang - Cambridge MA, US
Abby N. Deleault - Cambridge MA, US
Eric W. Marchese - Cambridge MA, US
Phu C. Nguyen - Cambridge MA, US
Chad C. Huval - Cambridge MA, US
Michael A. Bouchard - Cambridge MA, US
Arthur J. Coury - Cambridge MA, US
Christopher R. Loose - Cambridge MA, US
Assignee:
Semprus Biosciences Corporation - Boston MA
International Classification:
A61L 33/00
US Classification:
427 225, 424423, 530423, 530326, 530327
Abstract:
Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
Articles Having Non-Fouling Surfaces And Processes For Preparing The Same Including Pretreatment Of Articles
US Patent:
8632838, Jan 21, 2014
Filed:
Jun 9, 2011
Appl. No.:
13/156772
Inventors:
Laurence A. Roth - Cambridge MA, US
Zheng Zhang - Cambridge MA, US
Chad C. Huval - Cambridge MA, US
Michael A. Bouchard - Cambridge MA, US
Christopher R. Loose - Cambridge MA, US
Zheng Zhang - Cambridge MA, US
Chad C. Huval - Cambridge MA, US
Michael A. Bouchard - Cambridge MA, US
Christopher R. Loose - Cambridge MA, US
Assignee:
Semprus Biosciences Corporation - Cambridge MA
International Classification:
B05D 3/10, B32B 5/16
US Classification:
427 21, 427299, 427307, 427322, 428323
Abstract:
Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
Non-Fouling, Anti-Microbial, Anti-Thrombogenic Graft-From Compositons
US Patent:
2011030, Dec 15, 2011
Filed:
Jun 9, 2011
Appl. No.:
13/156677
Inventors:
Jun Li - Cambridge MA, US
Zheng Zhang - Cambridge MA, US
Chad C. Huval - Cambridge MA, US
Michael A. Bouchard - Cambridge MA, US
Arthur J. Coury - Cambridge MA, US
Christopher R. Loose - Cambridge MA, US
Zheng Zhang - Cambridge MA, US
Chad C. Huval - Cambridge MA, US
Michael A. Bouchard - Cambridge MA, US
Arthur J. Coury - Cambridge MA, US
Christopher R. Loose - Cambridge MA, US
International Classification:
B32B 3/00, D03D 15/00, D04H 13/00, B05D 3/10
US Classification:
428141, 427340, 428336, 442181, 442327
Abstract:
A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cmin a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.
Articles Having Non-Fouling Surfaces And Processes For Preparing The Same Including Applying A Primer Coat
US Patent:
2011030, Dec 15, 2011
Filed:
Jun 9, 2011
Appl. No.:
13/156936
Inventors:
Karen A. Schultz - Cambridge MA, US
Zheng Zhang - Cambridge MA, US
Chad C. Huval - Cambridge MA, US
Michael A. Bouchard - Cambridge MA, US
Christopher R. Loose - Cambridge MA, US
Zheng Zhang - Cambridge MA, US
Chad C. Huval - Cambridge MA, US
Michael A. Bouchard - Cambridge MA, US
Christopher R. Loose - Cambridge MA, US
International Classification:
B32B 3/00, B05D 1/36, B05D 5/00
US Classification:
4281951, 4274071
Abstract:
Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve coating the substrate to conceal or reduce flaws on or in the surface of the medical device or other article substrate, and thereafter forming a grafted polymer layer on the treated substrate surface.
Non-Fouling, Anti-Microbial, Anti-Thrombogenic Graft Compositions
US Patent:
2011030, Dec 15, 2011
Filed:
Jun 9, 2011
Appl. No.:
13/156708
Inventors:
Zheng Zhang - Cambridge MA, US
Jun Li - Cambridge MA, US
Chad C. Huval - Cambridge MA, US
Michael A. Bouchard - Cambridge MA, US
Arthur J. Coury - Cambridge MA, US
Christopher R. Loose - Cambridge MA, US
Jun Li - Cambridge MA, US
Chad C. Huval - Cambridge MA, US
Michael A. Bouchard - Cambridge MA, US
Arthur J. Coury - Cambridge MA, US
Christopher R. Loose - Cambridge MA, US
International Classification:
B32B 3/00, B32B 9/04, B32B 27/40, B32B 27/00, B32B 17/06, D04H 13/00, D03D 15/00, A61L 33/00, B32B 15/04
US Classification:
428336, 427 224, 4284111, 4284231, 428457, 428426, 442327, 442181, 428332, 428500
Abstract:
The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.