Inventors:
Ann B. Zimrin - Marriottsville MD
Thomas Maciag - Freeport ME
Michael S. Pepper - Geneva, CH
Roberto Montesano - Geneva, CH
Michael Wong - Derwood MD
Assignee:
Maine Medical Center Research Institute - Scarborough ME
International Classification:
C12P 2106
US Classification:
435 691, 435455, 4352523, 4353201
Abstract:
This invention relates to therapeutic and diagnostic methods and compositions based on Jagged/Notch proteins and nucleic acids, and on the role of their signaling pathway in endothelial cell migration and/or differentiation. In addition, this invention provides a substantially purified Jagged protein, as well as a substantially purified nucleic acid molecule or segment thereof encoding Jagged protein, or a functionally equivalent derivative, or allelic or species variant thereof.