Michael D Weil
Physician at Douglas Rd, Fort Collins, CO

2005013, Jun 16, 2005

Oct 13, 2004

10/965434

Michael Weil - Fort Collins CO, US
Terrence Moore - Pleasant Hill CA, US
Michelle Svatos - Oakland CA, US

A61M003/00, A61N005/00, H05G001/00

600004000

A system may include a radiation treatment agent to treat tissue in response to received X-ray radiation and an identifier associated with the radiation treatment agent. The identifier may be usable to identify a radiation treatment plan. In some embodiments, a radiation treatment plan associated with a patient is generated, the radiation treatment plan is associated with an identifier and a patient identifier identifying the patient, a radiation treatment agent is prepared for delivery to the patient according to the radiation treatment plan, and the radiation treatment agent is associated with the identifier.

2004011, Jun 17, 2004

Dec 17, 2002

10/320906

William Collins - Clayton CA, US
Michael Weil - Fort Collins CO, US

A61B005/05

600/407000, 600/427000

A system includes a surface to support a body and a CT scanner to acquire, based on a first set of one or more CT scanning parameters, a first set of CT data representing a volume within the body including a dose-enhancing agent. The system further includes a processor to determine a CT number associated with the volume based on the first set of CT data, and to determine a dose enhancement corresponding to the dose-enhancing agent within the volume based on a stored association between the CT number, the first set of one or more scanning parameters, and the dose enhancement.

8243877, Aug 14, 2012

Sep 12, 2007

11/853999

Michael D. Weil - Fort Collins CO, US

A61N 5/10

378 65, 600427

The present invention relates to the field of medical imaging and therapy of lesions that are detrimental to the body. The system is capable of both imaging and treatment with the same kilovoltage radiation source. Dual-use collimators produce a wide beam, which is not a pencil beam or a fan beam, to image and treat a target that has an enhanced radiation cross-section after taking up contrast agent containing a high-Z element. This results in increased radiation dose in the lesion. Furthermore, the significant drop in intensity of a low-energy radiation beam traveling through tissue is surmounted by continually aiming the beam at the target while moving it around the patient. Wide detectors opposing the radiation source permit the imaging and measurement of contrast in the target. More specifically this invention relates to a system, which optimizes delivery of kilovoltage x-rays to a lesion containing contrast agents in higher concentration than the surrounding normal tissues. Thereby subsequent delivery of radiation becomes cytotoxic upon interaction with the contrast.

2007028, Dec 6, 2007

Jun 5, 2007

11/758001

Michael Weil - Fort Collins CO, US

Sirius Medicine, LLC - Fort Collins CO

A61N 5/10, A61K 51/00, A61M 36/14

378065000, 424001110

Radiation has been used for many years to treat cancer patients. In the case of ionizing electromagnetic radiation, the incidental, extra dose to tissues surrounding the tumor is significant. The aim of this invention is to provide compounds and methods to enhance the absorbed radiation dose ratio, or other therapeutic compounds, in tumors verses normal tissue. The system concentrates contrast agents with high atomic number elements preferentially at the site of the tumor prior to administering radiotherapy, or preferentially concentrates other therapeutic compounds in the abnormal region. The agents are concentrated in a pathologic lesion following systemic or direct administration. Interaction of the ionizing radiation with the coupled compounds of this invention results in a significantly higher radiation dose to the tumor compared to surrounding tissues. The result is greater therapeutic efficacy with fewer side effects following treatment with low-energy radiation, or other agents. These compounds permit diagnostic uses in combination with the therapeutic use.

2006003, Feb 23, 2006

Dec 7, 2004

11/007117

Michael Weil - Fort Collins CO, US
Terrence Moore - Pleasant Hill CA, US
Michelle Svatos - Oakland CA, US

A61N 5/10

378065000

Embodiments may include determination of a treatment plan associated with a patient, the treatment plan including a first treatment mode in which a treatment agent is present within a portion of the patient and a second treatment mode in which the portion of the patient is irradiated, determination, independent from the second treatment mode, of whether the first treatment mode meets a first safety threshold, determination, independent from the first treatment mode, of whether the second treatment mode meets a second safety threshold, and determination of whether a combination of the first treatment mode and the second treatment mode meets a third safety threshold.

7481758, Jan 27, 2009

Apr 1, 2002

10/113511

Michael Weil - Fort Collins CO, US
Kevin N. Morris - Denver CO, US

Sirius Medicine, LLC - Fort Collins CO

A61N 5/02

600 2, 378 51, 378 64, 378 65, 378119, 4241551, 424 852, 600431

Contrast agents developed specifically for x-ray diagnostics provide dose-enhanced radiotherapy and radiosurgery. The presence of heavy elements, for example, gold or iron, from these contrast agents, even small quantities, leads to a major dose increase in target tissue when combined with in vivo calibration of the amount of contrast agent. The technique can also be used in combination with other techniques, such as focused x-rays, to achieve further enhancement of therapeutic ratio. The technique is enhanced by employing oil-based contrast agents, which will remain in the target much longer than conventional agents. Through optimization of the equipment it is possible to achieve very large ratios of dose in target to dose in healthy tissue.

2003001, Jan 16, 2003

Jun 20, 2002

10/176877

Webster Cash - Boulder CO, US
Michael Weil - Fort Collins CO, US
Kevin Morris - Denver CO, US

G21K001/06

378/084000

X-ray radiation from conventional electron-impact x-ray sources can be focused to very high intensity using a curved array of silicon wafers or other crystals having a spiral shape. This optic is of use for high-speed radiation treatment, radiosurgery, and radiotherapy.