Inventors:
Yvan Le Huerou - Boulder CO, US
James F. Blake - Boulder CO, US
Indrani W. Gunawardana - Boulder CO, US
Peter J. Mohr - Boulder CO, US
Eli M. Wallace - Boulder CO, US
Bin Wang - Boulder CO, US
Mark Joseph Chicarelli - Boulder CO, US
Michael Lyon - Boulder CO, US
Assignee:
Array BioPharma Inc. - Boulder CO
International Classification:
A61K 33/24, A61K 31/437, A61K 31/7068, A61K 31/4745, A61K 31/513, A61K 31/497, A61K 31/506, A61K 31/501, A61K 31/498, A61K 31/5377, A61K 31/55, A61P 35/00, C07D 471/04
US Classification:
424649, 51421018, 51421021, 51421707, 5142328, 514249, 51425201, 51425505, 514256, 514274, 514283, 514300, 514 49, 540597, 544127, 544238, 544333, 544355, 544405, 546113
Abstract:
Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.