MICHAEL C. WIEMANN
Physician in Providence, RI
License number
Rhode Island MD05732
Issued Date
8, 1980
Expiration Date
Jan 1, 1990
Category
Physician
Type
Allopathic Physician (MD)
Address
Address
Providence, RI
Education
Louisiana State Univ. at New Orleans School of Med
Professional information
Reduction Of The Severity Of 3'-Azido-3'-Deoxythymidine-Induced Anemia Using A Combination Of Benzylacyclouridine And Dipyridamole
US Patent:
4950466, Aug 21, 1990
Filed:
Jun 22, 1988
Appl. No.:
7/210882
Inventors:
Paul Calabresi - Barrington RI
James W. Darnowski - Barrington RI
Michael C. Wiemann - Providence RI
James W. Darnowski - Barrington RI
Michael C. Wiemann - Providence RI
International Classification:
A61K 4700, A61K 31505
US Classification:
424 10
Abstract:
The invention is directed to a method of inhibiting anemia caused by the administration of AZT to a patient which comprises administering to said patient an effective anemia-inhibiting amount of a combination of dipyridamole and 5-benzylacyclouridine. The invention is further directed to a pharmaceutical composition comprising as the active pharmaceutical agent a combination of dipyridamole and 5-benzylacyclouridine in association with a pharmaceutically acceptable carrier or diluent.
Reduction Of The Severity 3'-Azido-3'-Deoxythymidine-Induced Anemia Using Benzylacyclouridine
US Patent:
4874602, Oct 17, 1989
Filed:
Feb 22, 1988
Appl. No.:
7/158463
Inventors:
Paul Calabresi - Barrington RI
Michael C. Wiemann - Providence RI
Ming Y. W. Chu - Barrington RI
Michael C. Wiemann - Providence RI
Ming Y. W. Chu - Barrington RI
International Classification:
A61K 3170, A61K 31505
US Classification:
424 10
Abstract:
A method of reducing anemia caused by the administration of 3'-azido-3'-deoxythymidine to an animal which comprises treating said animal with a compound which inhibits the enzyme uridine phosphorylase in order to increase cellular uridine levels is disclosed. A particularly-effective compound is 5-benzylacyclouridine.