DR. MICHAEL C TRACY, M.D.
Medical Practice at Welch Rd, Palo Alto, CA
License number
California A109528
Category
Medical Practice
Type
Pediatrics
Address
Address
725 Welch Rd, Palo Alto, CA 94304
Phone
(650) 497-8979
Professional information
Michael C Tracy, Palo Alto CA
Specialties:
Pediatrics, General Practice
Work:
Pediatric Critical Care
750 Welch Rd, Palo Alto, CA 94304
750 Welch Rd, Palo Alto, CA 94304
Education:
Brown University (2008)
Dr. Michael C Tracy, Palo Alto CA - MD (Doctor of Medicine)
Specialties:
Pediatrics
Age:
47
Address:
725 Welch Rd STE 11, Palo Alto 94304
(650) 497-8979 (Phone)
(650) 497-8979 (Phone)
Certifications:
Pediatrics, 2011
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Brown University / Alpert Medical School
Graduated: 2008
Brown University / Alpert Medical School
Graduated: 2008
1, 2, 4-Benzotriazine Oxides As Radiosensitizers And Selective Cytotoxic Agents
US Patent:
6362184, Mar 26, 2002
Filed:
Oct 17, 1997
Appl. No.:
08/951873
Inventors:
William W. Lee - Palo Alto CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA
Assignee:
SRI International - Menlo Park CA
International Classification:
A61K 3153
US Classification:
514243, 5142325, 5142342, 514 84
Abstract:
A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitive hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.
1,2,4-Benzotriazine Oxides As Radiosensitizers And Selective Cytotoxic Agents
US Patent:
6828321, Dec 7, 2004
Filed:
Dec 17, 2001
Appl. No.:
10/022678
Inventors:
William W. Lee - Palo Alto CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA
Assignee:
SRI International - Menlo Park CA
International Classification:
A61K 3153
US Classification:
514243, 5142325, 5142342
Abstract:
A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.
1,2,4-Benzotriazine Oxides As Radiosensitizers And Selective Cytotoxic Agents
US Patent:
5624925, Apr 29, 1997
Filed:
Jan 26, 1995
Appl. No.:
8/378419
Inventors:
William W. Lee - Palo Alto CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA
Assignee:
SRI International - Menlo Park CA
International Classification:
A61K 3153, A61K 31535
US Classification:
514243
Abstract:
A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosentitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4- benzotriazine oxides is also disclosed.
1,2,4-Benzotriazine Oxides As Radiosensitizers And Selective Cytotoxic Agents
US Patent:
5849738, Dec 15, 1998
Filed:
May 30, 1995
Appl. No.:
8/453329
Inventors:
William W. Lee - Palo Alto CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA
Assignee:
SRI International - Menlo Park CA
International Classification:
A61K 3153, A61K 31535
US Classification:
514243
Abstract:
A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.
1, 2, 4-Benzotriazine Oxides As Radiosensitizers And Selective Cytotoxic Agents
US Patent:
2005015, Jul 14, 2005
Filed:
Dec 3, 2004
Appl. No.:
11/003809
Inventors:
William Lee - Palo Alto CA, US
J. Brown - Stanford CA, US
Edward Grange - Palo Alto CA, US
Abelardo Martinez - San Jose CA, US
Michael Tracy - Palo Alto CA, US
Daniel Pollart - Menlo Park CA, US
J. Brown - Stanford CA, US
Edward Grange - Palo Alto CA, US
Abelardo Martinez - San Jose CA, US
Michael Tracy - Palo Alto CA, US
Daniel Pollart - Menlo Park CA, US
International Classification:
A61K031/5377, A61K031/53
US Classification:
514234200, 514243000
Abstract:
A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.
Fluorinated 2-Nitroimidazole Analogs For Detecting Hypoxic Tumor Cells
US Patent:
5721265, Feb 24, 1998
Filed:
Jun 2, 1995
Appl. No.:
8/458178
Inventors:
Michael Tracy - Palo Alto CA
Andrew B. Kelson - San Carlos CA
Paul Workman - Wilmslow, GB2
Alexander D. Lewis - Bearsden, GB6
Eric O. Aboagye - Bearsden, GB6
Andrew B. Kelson - San Carlos CA
Paul Workman - Wilmslow, GB2
Alexander D. Lewis - Bearsden, GB6
Eric O. Aboagye - Bearsden, GB6
Assignee:
SRI International - Menlo Park CA
International Classification:
C07D23302, C07D23304, C07D23354, C07D23328, C07D23368, A61K 31415
US Classification:
514396
Abstract:
Agents useful for detecting hypoxic tumor cells are provided. The compounds have the structural formula (I) ##STR1## Methods of using the compounds to detect hypoxic tumor cells are also provided, as are pharmaceutical compositions formulated with the novel compounds.
Process For Preparing 1,2,4-Benzotriazine Oxides
US Patent:
5175287, Dec 29, 1992
Filed:
Sep 18, 1989
Appl. No.:
7/409480
Inventors:
William W. Lee - Palo Alto CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA
J. Martin Brown - Stanford CA
Edward W. Grange - Palo Alto CA
Abelardo P. Martinez - San Jose CA
Michael Tracy - Palo Alto CA
Daniel J. Pollart - Menlo Park CA
Assignee:
S R I International - Menlo Park CA
International Classification:
C07D253065
US Classification:
544183
Abstract:
A method of using 1,2,4-benzotriazine oxides, some of which are novel compounds, as radiosensitizers and selective cytotoxic agents is disclosed. These compounds are shown to specifically radiosensitize hypoxic tumor cells. Some are additionally disclosed to be useful as specific cytotoxic agents for these cells. They also show an unexpected ability to radiosensitize aerobic cells following or preceding a hypoxic incubation of the cells with the drug. This provides a basis for selective radiosensitization of tumors compared to normal cells. A novel method for preparing the 1,2,4-benzotriazine oxides is also disclosed.