Inventors:
Wei Zhang - Collegeville PA, US
Alan Maycock - Wayne PA, US
Michael Marella - Limerick PA, US
Virendra Kumar - Paoli PA, US
Forrest Gaul - Glen Moore PA, US
Michael Chang - Rochester MN, US
Deqi Guo - Phoenixville PA, US
International Classification:
A61K031/55, A61K031/445, A61K031/40
US Classification:
514217120, 514317000, 514408000, 540609000, 546234000, 548571000
Abstract:
Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided.
The compounds of formulae I, II, IIA, III, IIIA, IIIB, IIB-i, IV and IVA have the structure:
wherein