Inventors:
Michael R. Benoit - Denver CO, US
Scott J. Novick - Palo Alto CA, US
Assignee:
Codexis, Inc. - Redwood City CA
International Classification:
C12N 9/00, C12N 1/20, C12P 1/00
US Classification:
435183, 435197, 435232, 4352523, 43525233, 43525411, 4353201, 435262, 536 232
Abstract:
The present disclosure relates to β-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides formulations and uses of the polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering. Also provided are polynucleotides encoding the carbonic anhydrase polypeptides and host cells capable of expressing them.