MICHAEL B WILSON
Student, Health Care in Ann Arbor, MI

License number

Michigan 4301107292

Professional information

See more information about MICHAEL B WILSON at trustoria.com

Thiazolidinone Compounds Useful As Chemokine Inhibitors

US Patent:

6506751, Jan 14, 2003

Filed:

Nov 2, 2000

Appl. No.:

09/705219

Inventors:

Stephanie Elizabeth Ault Justus - Livonia MI
Helen Tsenwhei Lee - Ann Arbor MI
Jason Keith Pontrello - Kalamazoo MI
Bruce David Roth - Plymouth MI
Karen Elaine Sexton - Ann Arbor MI
Michael William Wilson - Ann Arbor MI

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C07D41306

US Classification:

5142368, 546175, 546187, 546194, 546209, 544133, 548182, 548183, 548186, 548187, 514314, 514316, 514326, 514369

Abstract:

Disclosed are compounds of the Formula I wherein: Z is C or nothing, provided that when Z is nothing, R and R are nothing; A is S, S O or O S O; R and R are independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy, (un)substituted aryl, (un)substituted arylalkyl, (un)substituted heteroaryl or(un)substituted heteroarylakyl; R and R independently represent hydrogen, lower alkyl, cycloalkyl, aminoalkyl, mono- or dialkylaminoalkyl, (un)substituted aryl or (un)substituted heteroaryl; R represents a (un)substituted carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms; or R is (CR R )â(CH ) âXR R ; X is S or N; R , R , R , R , and n are as defined in the specification. The compounds are useful in the treatment and prevention of the AIDS virus. Intermediates useful in the preparation of the final products, pharmaceutical compositions containing the final products are also taught.

Quinazolines As Mmp-13 Inhibitors

US Patent:

2002019, Dec 19, 2002

Filed:

Feb 13, 2002

Appl. No.:

10/075954

Inventors:

Charles Andrianjara - Fresnes, FR
Nicole Barvian - Ann Arbor MI, US
Bernard Gaudilliere - Nanterre, FR
Henri Jacobelli - Paray Vieille Poste, FR
Daniel Ortwine - Saline MI, US
William Patt - Chelsea MI, US
Ly Pham - Grand Rapids MI, US
Catherine Kostlan - Saline MI, US
Michael Wilson - Ann Arbor MI, US

International Classification:

C07D487/02, A61K031/519, A61K031/517, A61K031/525, C07D239/72

US Classification:

514/248000, 514/251000, 514/262100, 514/264100, 544/236000, 544/256000, 544/257000, 544/279000, 544/285000, 514/266300

Abstract:

A compound selected from those of formula (I): in which: Rrepresents a group selected from hydrogen, amino, alkyl, alkenyl, aminoalkyl, aryl, arylalkyl, heterocycle, and cycloalkylalkyl, optionally substituted, W represents oxygen, sulfhur, or N—R′, in which R′ is as defined in the description, X, Xand Xrepresent nitrogen or —C—Rin which Ris as defined in the description, Y represents oxygen, sulfhur, —NH, or —N(C-C)alkyl, Z represents oxygen, sulfhur, —NRin which Ris as defined in the description, and 59 optionally carbon atom, n is an integer from 1 to 8 inclusive, Zrepresents —CRRwherein Rand Rare as defined in the description, A represents aromatic or non-aromatic, heterocyclic or non-heterocyclic ring system, m is an integer from 0 to 7 inclusive, the group(s) Ris (are) is as defined in the description, Rrepresents hydrogen, alkyl, alkenyl, alkynyl, ot a group of formula: in which Z, B, R, P and q are as defined in the description, optionally, the racemic forms thereof, isomers thereof, N-oxydes thereof, and the pharmaceutically acceptable salts thereof, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix metalloprotease.

Histidine And Homohistidine Derivatives As Inhibitors Of Protein Farnesyltransferase

US Patent:

5571792, Nov 5, 1996

Filed:

Jun 30, 1994

Appl. No.:

8/268364

Inventors:

Gary L. Bolton - Ann Arbor MI
John C. Hodges - Ann Arbor MI
Michael W. Wilson - Ann Arbor MI

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K 31415, C07D23364, C07K 5078, C07K 5097

US Classification:

514 18

Abstract:

Novel inhibitors of protein farnesyltransferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.

Rapid Purification By Polymer Supported Quench

US Patent:

6306959, Oct 23, 2001

Filed:

Oct 15, 1998

Appl. No.:

9/171258

Inventors:

Gary L. Bolton - Ann Arbor MI
Richard J. Booth - Ypsilanti MI
Mark W. Creswell - Chelsea MI
John C. Hodges - Ann Arbor MI
Joseph S. Warmus - Ann Arbor MI
Michael W. Wilson - Ann Arbor MI

Assignee:

Warner Lambert Company - Ann Arbor MI

International Classification:

C08G 6348

US Classification:

525 541

Abstract:

Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

3-Aryloxy And 3-Heteroaryloxy Substituted Benzo[B]Thiophenes As Therapeutic Agents

US Patent:

2004025, Dec 23, 2004

Filed:

Jun 3, 2004

Appl. No.:

10/860348

Inventors:

Michelle Bruendl - Ann Arbor MI, US
Michael Connolly - Ypsilanti MI, US
Annise Goodman - West Bloomfield MI, US
Rocco Gogliotti - Pinckney MI, US
Helen Lee - Ann Arbor MI, US
Mark Plummer - Dexter MI, US
Karen Sexton - Chelsea MI, US
Aurash Shahripour - Ann Arbor MI, US
Greg Reichard - Ann Arbor MI, US
Melean Visnick - Ann Arbor MI, US
Michael Wilson - Ann Arbor MI, US

International Classification:

A61K031/41, C 07D 4 9/02

US Classification:

514/381000, 548/251000

Abstract:

The present invention provides benzo[b]thiophenes of Formula I: wherein R, R, R, R, R, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

Hetero Biaryl Derivatives As Matrix Metalloproteinase Inhibitors

US Patent:

2009002, Jan 29, 2009

Filed:

Nov 29, 2006

Appl. No.:

11/564453

Inventors:

Amy Mae Bunker - Ann Arbor MI, US
Mark Anthony Morris - Ypsilanti MI, US
Patrick Michael O'Brien - Stockbridge MI, US
Michael William Wilson - Ann Arbor MI, US

Assignee:

WARNER-LAMBERT COMPANY - Ann Arbor MI
WARNER-LAMBERT COMPANY LLC - Ann Arbor MI

International Classification:

A61K 31/5377, C07D 257/04, A61K 31/41, C07D 277/20, A61K 31/433, A61K 31/44, A61K 31/4245, A61K 31/421, A61P 11/00, A61P 19/00, A61P 9/00, C07D 263/30, C07D 271/06, C07D 213/02, C07D 285/06, A61K 31/426, C07D 295/00

US Classification:

5142362, 548253, 514381, 548204, 514365, 544132, 548127, 514361, 5462684, 514340, 548131, 514364, 548235, 514374

Abstract:

This invention provides compounds defined by Formula Ior a pharmaceutically acceptable salt thereof, wherein R, Q, S, T, U, V, and Rare as defined in the specification. The invention also provides pharmaceutical compositions and methods of treating diseases.

Fused Bicyclic Metalloproteinase Inhibitors

US Patent:

6949651, Sep 27, 2005

Filed:

Aug 5, 2003

Appl. No.:

10/634162

Inventors:

Michael William Wilson - Ann Arbor MI, US

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

C07D495/04, C07D471/04, A61K031/4365, A61K031/437

US Classification:

546114, 546112, 546115, 546118, 514302, 514303, 514299, 514301

Abstract:

The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula wherein A, B, X, Y, and Rare as defined in the specification, and to pharmaceutical compositions and methods of treating arthritis, inflammation, cancer and other disorders.

Hetero Biaryl Derivatives As Matrix Metalloproteinase Inhibitors

US Patent:

7179822, Feb 20, 2007

Filed:

Aug 5, 2003

Appl. No.:

10/634709

Inventors:

Amy Mae Bunker - Ann Arbor MI, US
Mark Anthony Morris - Ypsilanti MI, US
Patrick Michael O'Brien - Stockbridge MI, US
Michael William Wilson - Ann Arbor MI, US

Assignee:

Warner-Lambert Company - Morris Plains NJ
Warner-Lambert Company LLC - Morris Plains NJ

International Classification:

C07D 401/04, C07D 401/14, C07D 403/14, A61K 31/40, A61K 31/44, A61P 19/02

US Classification:

514340, 514341, 514342, 5462681, 5462684

Abstract:

This invention provides compounds defined by Formula I.

Alkynylated Quinazoline Compounds

US Patent:

6962922, Nov 8, 2005

Filed:

Oct 11, 2002

Appl. No.:

10/269197

Inventors:

Bernard Gaudilliere - Nanterre, FR
Henri Jacobelli - Paray Vieille Poste, FR
Joseph Armand Picard - Canton MI, US
Michael William Wilson - Ann Arbor MI, US

Assignee:

Warner-Lambert Company LLC - Morris Plains NJ

International Classification:

C07D239/96, C07D403/06, C07D401/10, A61K031/517, A61P019/02

US Classification:

5142662, 51426621, 51426623, 51426624, 5142663, 51426631, 433284, 433285, 433287, 433290

Abstract:

A compound selected from those of formula (I):.

Pyridine Matrix Metalloproteinase Inhibitors

US Patent:

6881743, Apr 19, 2005

Filed:

Feb 8, 2002

Appl. No.:

10/071073

Inventors:

Nicole Chantel Barvian - Ann Arbor MI, US
David Thomas Connor - Ann Arbor MI, US
Patrick Michael O'Brien - Stockbridge MI, US
Daniel Fred Ortwine - Saline MI, US
William Chester Patt - Chelsea MI, US
Kevon Ray Shuler - Chelsea MI, US
Michael William Wilson - Ann Arbor MI, US

Assignee:

Warner-Lambert Company - Morris Plains NJ

International Classification:

A61K031/4412, C07D405/12

US Classification:

514338, 5462841

Abstract:

Selective MMP-13 inhibitors are pyridine derivatives of the formula or a pharmaceutically acceptable salt thereof,.