MICHAEL B WILSON
Student, Health Care in Ann Arbor, MI
License number
Michigan 4301107292
Category
Student, Health Care
Type
Student in an Organized Health Care Education/Training Program
Address
Address
1500 Tc SPC 5312, Ann Arbor, MI 48109
Phone
(734) 763-4210
Professional information
Thiazolidinone Compounds Useful As Chemokine Inhibitors
US Patent:
6506751, Jan 14, 2003
Filed:
Nov 2, 2000
Appl. No.:
09/705219
Inventors:
Stephanie Elizabeth Ault Justus - Livonia MI
Helen Tsenwhei Lee - Ann Arbor MI
Jason Keith Pontrello - Kalamazoo MI
Bruce David Roth - Plymouth MI
Karen Elaine Sexton - Ann Arbor MI
Michael William Wilson - Ann Arbor MI
Helen Tsenwhei Lee - Ann Arbor MI
Jason Keith Pontrello - Kalamazoo MI
Bruce David Roth - Plymouth MI
Karen Elaine Sexton - Ann Arbor MI
Michael William Wilson - Ann Arbor MI
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D41306
US Classification:
5142368, 546175, 546187, 546194, 546209, 544133, 548182, 548183, 548186, 548187, 514314, 514316, 514326, 514369
Abstract:
Disclosed are compounds of the Formula I wherein: Z is C or nothing, provided that when Z is nothing, R and R are nothing; A is S, S O or O S O; R and R are independently hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy, (un)substituted aryl, (un)substituted arylalkyl, (un)substituted heteroaryl or(un)substituted heteroarylakyl; R and R independently represent hydrogen, lower alkyl, cycloalkyl, aminoalkyl, mono- or dialkylaminoalkyl, (un)substituted aryl or (un)substituted heteroaryl; R represents a (un)substituted carbocyclic group containing from 3-7 members, up to two of which members are optionally hetero atoms; or R is (CR R )â(CH ) âXR R ; X is S or N; R , R , R , R , and n are as defined in the specification. The compounds are useful in the treatment and prevention of the AIDS virus. Intermediates useful in the preparation of the final products, pharmaceutical compositions containing the final products are also taught.
Quinazolines As Mmp-13 Inhibitors
US Patent:
2002019, Dec 19, 2002
Filed:
Feb 13, 2002
Appl. No.:
10/075954
Inventors:
Charles Andrianjara - Fresnes, FR
Nicole Barvian - Ann Arbor MI, US
Bernard Gaudilliere - Nanterre, FR
Henri Jacobelli - Paray Vieille Poste, FR
Daniel Ortwine - Saline MI, US
William Patt - Chelsea MI, US
Ly Pham - Grand Rapids MI, US
Catherine Kostlan - Saline MI, US
Michael Wilson - Ann Arbor MI, US
Nicole Barvian - Ann Arbor MI, US
Bernard Gaudilliere - Nanterre, FR
Henri Jacobelli - Paray Vieille Poste, FR
Daniel Ortwine - Saline MI, US
William Patt - Chelsea MI, US
Ly Pham - Grand Rapids MI, US
Catherine Kostlan - Saline MI, US
Michael Wilson - Ann Arbor MI, US
International Classification:
C07D487/02, A61K031/519, A61K031/517, A61K031/525, C07D239/72
US Classification:
514/248000, 514/251000, 514/262100, 514/264100, 544/236000, 544/256000, 544/257000, 544/279000, 544/285000, 514/266300
Abstract:
A compound selected from those of formula (I):
in which: Rrepresents a group selected from hydrogen, amino, alkyl, alkenyl, aminoalkyl, aryl, arylalkyl, heterocycle, and cycloalkylalkyl, optionally substituted, W represents oxygen, sulfhur, or N—R′, in which R′ is as defined in the description, X, Xand Xrepresent nitrogen or —C—Rin which Ris as defined in the description, Y represents oxygen, sulfhur, —NH, or —N(C-C)alkyl, Z represents oxygen, sulfhur, —NRin which Ris as defined in the description, and 59 optionally carbon atom, n is an integer from 1 to 8 inclusive, Zrepresents —CRRwherein Rand Rare as defined in the description, A represents aromatic or non-aromatic, heterocyclic or non-heterocyclic ring system, m is an integer from 0 to 7 inclusive, the group(s) Ris (are) is as defined in the description, Rrepresents hydrogen, alkyl, alkenyl, alkynyl, ot a group of formula:
in which Z, B, R, P and q are as defined in the description, optionally, the racemic forms thereof, isomers thereof, N-oxydes thereof, and the pharmaceutically acceptable salts thereof, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix metalloprotease.
Histidine And Homohistidine Derivatives As Inhibitors Of Protein Farnesyltransferase
US Patent:
5571792, Nov 5, 1996
Filed:
Jun 30, 1994
Appl. No.:
8/268364
Inventors:
Gary L. Bolton - Ann Arbor MI
John C. Hodges - Ann Arbor MI
Michael W. Wilson - Ann Arbor MI
John C. Hodges - Ann Arbor MI
Michael W. Wilson - Ann Arbor MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K 31415, C07D23364, C07K 5078, C07K 5097
US Classification:
514 18
Abstract:
Novel inhibitors of protein farnesyltransferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.
Rapid Purification By Polymer Supported Quench
US Patent:
6306959, Oct 23, 2001
Filed:
Oct 15, 1998
Appl. No.:
9/171258
Inventors:
Gary L. Bolton - Ann Arbor MI
Richard J. Booth - Ypsilanti MI
Mark W. Creswell - Chelsea MI
John C. Hodges - Ann Arbor MI
Joseph S. Warmus - Ann Arbor MI
Michael W. Wilson - Ann Arbor MI
Richard J. Booth - Ypsilanti MI
Mark W. Creswell - Chelsea MI
John C. Hodges - Ann Arbor MI
Joseph S. Warmus - Ann Arbor MI
Michael W. Wilson - Ann Arbor MI
Assignee:
Warner Lambert Company - Ann Arbor MI
International Classification:
C08G 6348
US Classification:
525 541
Abstract:
Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.
3-Aryloxy And 3-Heteroaryloxy Substituted Benzo[B]Thiophenes As Therapeutic Agents
US Patent:
2004025, Dec 23, 2004
Filed:
Jun 3, 2004
Appl. No.:
10/860348
Inventors:
Michelle Bruendl - Ann Arbor MI, US
Michael Connolly - Ypsilanti MI, US
Annise Goodman - West Bloomfield MI, US
Rocco Gogliotti - Pinckney MI, US
Helen Lee - Ann Arbor MI, US
Mark Plummer - Dexter MI, US
Karen Sexton - Chelsea MI, US
Aurash Shahripour - Ann Arbor MI, US
Greg Reichard - Ann Arbor MI, US
Melean Visnick - Ann Arbor MI, US
Michael Wilson - Ann Arbor MI, US
Michael Connolly - Ypsilanti MI, US
Annise Goodman - West Bloomfield MI, US
Rocco Gogliotti - Pinckney MI, US
Helen Lee - Ann Arbor MI, US
Mark Plummer - Dexter MI, US
Karen Sexton - Chelsea MI, US
Aurash Shahripour - Ann Arbor MI, US
Greg Reichard - Ann Arbor MI, US
Melean Visnick - Ann Arbor MI, US
Michael Wilson - Ann Arbor MI, US
International Classification:
A61K031/41, C 07D 4 9/02
US Classification:
514/381000, 548/251000
Abstract:
The present invention provides benzo[b]thiophenes of Formula I:
wherein R, R, R, R, R, and L have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.
Hetero Biaryl Derivatives As Matrix Metalloproteinase Inhibitors
US Patent:
2009002, Jan 29, 2009
Filed:
Nov 29, 2006
Appl. No.:
11/564453
Inventors:
Amy Mae Bunker - Ann Arbor MI, US
Mark Anthony Morris - Ypsilanti MI, US
Patrick Michael O'Brien - Stockbridge MI, US
Michael William Wilson - Ann Arbor MI, US
Mark Anthony Morris - Ypsilanti MI, US
Patrick Michael O'Brien - Stockbridge MI, US
Michael William Wilson - Ann Arbor MI, US
Assignee:
WARNER-LAMBERT COMPANY - Ann Arbor MI
WARNER-LAMBERT COMPANY LLC - Ann Arbor MI
WARNER-LAMBERT COMPANY LLC - Ann Arbor MI
International Classification:
A61K 31/5377, C07D 257/04, A61K 31/41, C07D 277/20, A61K 31/433, A61K 31/44, A61K 31/4245, A61K 31/421, A61P 11/00, A61P 19/00, A61P 9/00, C07D 263/30, C07D 271/06, C07D 213/02, C07D 285/06, A61K 31/426, C07D 295/00
US Classification:
5142362, 548253, 514381, 548204, 514365, 544132, 548127, 514361, 5462684, 514340, 548131, 514364, 548235, 514374
Abstract:
This invention provides compounds defined by Formula Ior a pharmaceutically acceptable salt thereof,
wherein R, Q, S, T, U, V, and Rare as defined in the specification. The invention also provides pharmaceutical compositions and methods of treating diseases.
Fused Bicyclic Metalloproteinase Inhibitors
US Patent:
6949651, Sep 27, 2005
Filed:
Aug 5, 2003
Appl. No.:
10/634162
Inventors:
Michael William Wilson - Ann Arbor MI, US
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
C07D495/04, C07D471/04, A61K031/4365, A61K031/437
US Classification:
546114, 546112, 546115, 546118, 514302, 514303, 514299, 514301
Abstract:
The present invention relates to fused bicyclic metalloproteinase inhibitors of the formula
wherein A, B, X, Y, and Rare as defined in the specification, and to pharmaceutical compositions and methods of treating arthritis, inflammation, cancer and other disorders.
Hetero Biaryl Derivatives As Matrix Metalloproteinase Inhibitors
US Patent:
7179822, Feb 20, 2007
Filed:
Aug 5, 2003
Appl. No.:
10/634709
Inventors:
Amy Mae Bunker - Ann Arbor MI, US
Mark Anthony Morris - Ypsilanti MI, US
Patrick Michael O'Brien - Stockbridge MI, US
Michael William Wilson - Ann Arbor MI, US
Mark Anthony Morris - Ypsilanti MI, US
Patrick Michael O'Brien - Stockbridge MI, US
Michael William Wilson - Ann Arbor MI, US
Assignee:
Warner-Lambert Company - Morris Plains NJ
Warner-Lambert Company LLC - Morris Plains NJ
Warner-Lambert Company LLC - Morris Plains NJ
International Classification:
C07D 401/04, C07D 401/14, C07D 403/14, A61K 31/40, A61K 31/44, A61P 19/02
US Classification:
514340, 514341, 514342, 5462681, 5462684
Abstract:
This invention provides compounds defined by Formula I.
Alkynylated Quinazoline Compounds
US Patent:
6962922, Nov 8, 2005
Filed:
Oct 11, 2002
Appl. No.:
10/269197
Inventors:
Bernard Gaudilliere - Nanterre, FR
Henri Jacobelli - Paray Vieille Poste, FR
Joseph Armand Picard - Canton MI, US
Michael William Wilson - Ann Arbor MI, US
Henri Jacobelli - Paray Vieille Poste, FR
Joseph Armand Picard - Canton MI, US
Michael William Wilson - Ann Arbor MI, US
Assignee:
Warner-Lambert Company LLC - Morris Plains NJ
International Classification:
C07D239/96, C07D403/06, C07D401/10, A61K031/517, A61P019/02
US Classification:
5142662, 51426621, 51426623, 51426624, 5142663, 51426631, 433284, 433285, 433287, 433290
Abstract:
A compound selected from those of formula (I):.
Pyridine Matrix Metalloproteinase Inhibitors
US Patent:
6881743, Apr 19, 2005
Filed:
Feb 8, 2002
Appl. No.:
10/071073
Inventors:
Nicole Chantel Barvian - Ann Arbor MI, US
David Thomas Connor - Ann Arbor MI, US
Patrick Michael O'Brien - Stockbridge MI, US
Daniel Fred Ortwine - Saline MI, US
William Chester Patt - Chelsea MI, US
Kevon Ray Shuler - Chelsea MI, US
Michael William Wilson - Ann Arbor MI, US
David Thomas Connor - Ann Arbor MI, US
Patrick Michael O'Brien - Stockbridge MI, US
Daniel Fred Ortwine - Saline MI, US
William Chester Patt - Chelsea MI, US
Kevon Ray Shuler - Chelsea MI, US
Michael William Wilson - Ann Arbor MI, US
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K031/4412, C07D405/12
US Classification:
514338, 5462841
Abstract:
Selective MMP-13 inhibitors are pyridine derivatives of the formula
or a pharmaceutically acceptable salt thereof,.