Michael Anthony Fleming
Anesthesiologist Assistant at Terry St, Longmont, CO

License number

Colorado 6566

Issued Date

Aug 4, 2010

Renew Date

Nov 1, 2015

Expiration Date

Oct 31, 2017

Type

Chiropractic

Address

2030 Terry St SUITE A, Longmont, CO 80501

Professional information

Synthesis Of 3,6-Dialkyl-5,6-Dihydro-4-Hydroxy-Pyran-2-One

US Patent:

6743927, Jun 1, 2004

Filed:

Feb 10, 2003

Appl. No.:

10/364547

Inventors:

Michael P. Fleming - Longmont CO
Yeun-Kwei Han - Louisville CO
Lewis M. Hodges - Longmont CO
David A. Johnston - Louisville CO
Roger P. Micheli - Louisville CO
Kurt Puentener - Basel, CH
Chris R. Roberts - Berthoud CO
Michelangelo Scalone - Birsfelden, CH
Mark A. Schwindt - Boulder CO
Robert J. Topping - Longmont CO

Assignee:

Roche Colorado Corporation - Boulder CO

International Classification:

C07D30932

US Classification:

549292, 549294

Abstract:

The present invention relates to a novel process for producing a -lactone of the formula: using an acyl halide of the formula: wherein R , R R and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)- -lactone.

Synthesis Of 3,6-Dialkyl-5,6-Dihydro-4-Hydroxy-Pyran-2-One

US Patent:

6545165, Apr 8, 2003

Filed:

Sep 22, 2000

Appl. No.:

09/668834

Inventors:

Assignee:

Roche Colorado Corporation - Boulder CO

International Classification:

C07D30932

US Classification:

549292, 549294

Abstract:

Preparation Of Mibefradil Via An Acetamide Anion

US Patent:

5808088, Sep 15, 1998

Filed:

Apr 14, 1998

Appl. No.:

/060151

Inventors:

Peter J. Harrington - Louisville CO
Michael P. Fleming - Longmont CO

Assignee:

Roche Colorado Corporation - Boulder CO

International Classification:

C07D23514

US Classification:

5483097

Abstract:

A method of preparing 2-�2-{�3-(1H-benzimidazol-2-yl)propyl!methylamino)}ethyl!-6-fluoro-1-isopr opyl-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate comprises contacting 6-fluoro-1-isopropyl-3,4-dihydro-1H-naphthalen-2-one with the dianion of N-�3-(1H-benzimidazol-2-yl)propyl!-N-methylacetamide to form N-�3-(1H-benzimidazol-2-yl)propyl!-2-(6-fluoro-2-hydroxy-1-isopropyl-1,2,3 ,4-tetrahydronaphthalen-2-yl)-N-methylacetamide, reducing this to 2-�2-{�3-(1H-benzimidazol-2-yl)propyl!methylamino}ethyl!-6-fluoro-1-isopro pyl-1,2,3,4-tetrahydronaphthalen-2-ol, and treating the 2-�2-{�3-(1H-benzimidazol-2-yl)propyl!methylamino}ethyl!-6-fluoro-1-isopro pyl-1,2,3,4-tetrahydronaphthalen-2-ol with methoxyacetic acid or an activated derivative of methoxyacetic acid. The invention is particularly applicable to the preparation of mibefradil, (lS,2S)-2-�2-{�3-(1H-benzimidazol-2-yl)propyl!methylamino}ethyl!-6-fluoro- 1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate, and its dihydrochloride salt. N-�3-(1H-Benzimidazol-2-yl)propyl!-N-methylacetamide, and the acetic acid solvate of 2-�2- {�3-(1H-benzimidazol-2-yl)propyl!methylamino}ethyl!-6-fluoro-1-isopropyl-1 ,2,3,4-tetrahydronaphthalen-2-ol dioxalate, are new.

Process For Preparing (+)-2,3-Dihydro-1H-Pyrrolo[1,2-A]Pyrrole-1,7-Dicarboxylates

US Patent:

4874872, Oct 17, 1989

Filed:

Oct 11, 1988

Appl. No.:

7/255799

Inventors:

Michael P. Fleming - Longmont CO
Hiralal N. Khatri - Louisville CO
George C. Schloemer - Lyons CO

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

C07D20716

US Classification:

548531

Abstract:

2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates of the formula, ##STR1## in which each R is independently H or lower alkyl, are prepared from di(lower alkyl) 1,3-acetonedicarboxylates.

Process For Preparing (+)-2,3-Dihydro-1H-Pyrrolo[1,2-A]Pyrrole-1,7-Dicarboxylates

US Patent:

4835288, May 30, 1989

Filed:

Jan 14, 1987

Appl. No.:

7/003162

Inventors:

Hiralal N. Khatri - Louisville CO
Michael P. Fleming - Longmont CO
George C. Schloemer - Lyons CO

Assignee:

Syntex Inc. - Palo Alto CA

International Classification:

C07D48704

US Classification:

548453

Abstract:

2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates of the formula, ##STR1## in which each R is independently H or lower alkyl, are prepared from di(lower alkyl) 1,3-acetone-dicarboxylates.

Synthesis Of 3,6-Dialkyl-5,6-Dihydro-4-Hydroxy-Pyran-2-One

US Patent:

6858749, Feb 22, 2005

Filed:

Feb 10, 2003

Appl. No.:

10/364536

Inventors:

Michael P. Fleming - Longmont CO, US
Yeun-Kwei Han - Louisville CO, US
Lewis M. Hodges - Longmont CO, US
David A. Johnston - Louisville CO, US
Roger P. Micheli - Louisville CO, US
Kurt Puentener - Basel, CH
Chris R. Roberts - Berthoud CO, US
Michelangelo Scalone - Birsfelden, CH
Mark A. Schwindt - Boulder CO, US
Robert J. Topping - Longmont CO, US

Assignee:

Roche Colorado Corporation - Boulder CO

International Classification:

C07C069/66

US Classification:

560179, 560188

Abstract:

The present invention relates to a novel process for producing a δ-lactone of the formula: using an acyl halide of the formula: wherein R, RRand X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-δ-lactone.

Process For Preparing (+)-2,3-Dihydro-1H-Pyrrolo[1,2-A]Pyrrole-1,7-Dicarboxylates

US Patent:

4937368, Jun 26, 1990

Filed:

Jan 23, 1989

Appl. No.:

7/299701

Inventors:

Hiralal N. Khatri - Louisville CO
Michael P. Fleming - Longmont CO
George C. Schloemer - Lyons CO

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

C07C14368, C07C10120

US Classification:

558 48

Abstract:

2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates of the formula, ##STR1## in which each R is independently H or lower alkyl, are prepared from from di(lower alkyl) 1,3-acetone-dicarboxylates.

Process For Preparing (+)-2,3-Dihydro-1H-Pyrrolo[1,2-A]Pyrrole-1-Carboxylic Acid And Related Compounds

US Patent:

4874871, Oct 17, 1989

Filed:

Mar 25, 1987

Appl. No.:

7/030774

Inventors:

Michael P. Fleming - Longmont CO
George C. Schloemer - Lyons CO
Hiralal N. Khatri - Louisville CO

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

C07D48704, C07D207337, C07D207333

US Classification:

548543

Abstract:

2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid compounds of the formula, ##STR1## in which Y is OH; O. sup. - M. sup. +, wherein M is an alkali metal; or NRR', wherein R is lower alkyl and R' is lower alkyl or aryl, or NRR' is the residue of a saturated cyclic amine, are prepared from pyrrole.

Process For Isolating Therapeutic Peptides

US Patent:

2010026, Oct 14, 2010

Filed:

Apr 9, 2010

Appl. No.:

12/757357

Inventors:

Michael Paul Fleming - Longmont CO, US
Raymond Dennis Petersen - Thorton CO, US

International Classification:

C07K 7/08

US Classification:

530327

Abstract:

Disclosed are methods of isolating linaclotide, a cyclized 14-amino-acid peptide with three disulfide bonds. The sequence consists of Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr with disulfide bridges between the cysteine residues at positions 1 and 6, 2 and 10, and 5 and 13. The drug acts as a GCC superagonist, elevating intracellular cGMP composition for treating various disorders, including gastrointestinal disorders, obesity, congestive heart failure and benign prostatic hyperplasia.

Process For Preparing (.+-.)-2,3-Dihydro-1H-Pyrrolo[1,2-A]Pyrrole-1,7-Dicarboxylates

US Patent:

4849526, Jul 18, 1989

Filed:

Jan 14, 1987

Appl. No.:

7/003104

Inventors:

Michael P. Fleming - Longmont CO
Hiralal N. Khatri - Louisville CO
George C. Schloemer - Lyons CO

Assignee:

Syntex (U.S.A.) Inc. - Palo Alto CA

International Classification:

C07D48706

US Classification:

548453

Abstract:

2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylate intermediates of the formula, ##STR1## in which each R is independently H or lower alkyl, are prepared from di(lower alkyl) 1,3-acetonedicarboxylates.