Inventors:
Scott P. Runyon - Hillsborough NC, US
Michael A. Rogawski - Sacramento CA, US
John Kepler - Raleigh NC, US
Hernan Navarro - Chapel Hill NC, US
Rafal Kaminski - Waterloo, BE
Matthew Orr - Raleigh NC, US
Kevin M. Cook - Fairfax Station VA, US
Assignee:
Research Triangle Institute - Research Triangle Park NC
The United States of America, as represented by the Secretary, Department of Health and Human Services - Washington DC
International Classification:
C07J 41/00
Abstract:
This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.