Inventors:
Michael Valentino - Philadelphia PA, US
Scott A. Waldman - Ardmore PA, US
Assignee:
THOMAS JEFFERSON UNIVERSITY - Philadelphia PA
International Classification:
A61K 38/17, A61P 3/00, A61P 1/12, A61K 35/74
Abstract:
Compositions comprising a guanylyl cyclase C agonist formulated for sustained specific release of an amount effective to suppress appetite when administered orally to an individual are disclosed. Compositions comprising a guanylyl cyclase C agonist formulated for intravenous delivery in an amount effective to suppress appetite when administered intravenously to an individual are also disclosed. Methods of suppressing appetite in an individual are disclosed.