Inventors:
Wayne Livingston Cody - Saline MI
Patricia DePue - Canton MI
Annette Marian Doherty - Ann Arbor MI
John Xiaoqiang He - Ypsilanti MI
Michael Douglas Taylor - Ann Arbor MI
Assignee:
Warner-Lambert Company - Morris Plains NJ
International Classification:
A61K 3800, C07K 500, C07K 700
Abstract:
Novel antagonists of endothelin are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, metabolic, endocrinological, neurological disorders, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, Raynaud's disease, percutaneous transluminal coronary angioplasty or restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, ischemic bowel disease, and diabetes.