Inventors:
Albert Kudzovi Amegadzie - Indianapolis IN, US
Kevin Matthew Gardinier - Indianapolis IN, US
Erik James Hembre - Indianapolis IN, US
Jian Eric Hong - Carmel IN, US
Louis Nickolaus Jungheim - Indianapolis IN, US
Brian Stephen Muehl - Greenwood IN, US
David Michael Remick - Fishers IN, US
Michael Alan Robertson - Indianapolis IN, US
Kenneth Allen Savin - Indianapolis IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 31/41, C07D 249/04
Abstract:
This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C-Calkane-diyl; Ris phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C-Calkyl, C-Calkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; Ris a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH).