Inventors:
Mias Pretorius - Nashville TN, US
Nancy Brown - Nashville TN, US
Laine Murphey - Nashville TN, US
Assignee:
VANDERBILT UNIVERSITY - Nashville TN
International Classification:
A61K 31/00, A61K 38/12, A61K 31/4745, A61K 31/66
US Classification:
514009000, 435375000, 514114000, 514285000, 514291000
Abstract:
The present invention regards bradykinin receptor antagonists for treatment of a medical condition. In particular, the medical condition follows cardiopulmonary bypass. In specific embodiments, bradykinin receptor antagonists are used for the treatment of protamine-induced hypotension and/or fibrinolysis.