Inventors:
Melton B. Affrime - Warren NJ, US
Christopher R. Banfield - High Bridge NJ, US
Samir K. Gupta - East Brunswick NJ, US
Desmond Padhi - Thousand Oaks CA, US
Assignee:
Schering Corporation - Kenilworth NJ
International Classification:
A61K 31/44
Abstract:
A method of treating and/or preventing allergic and inflammatory conditions of the skin or upper and lower airway passages, e. g. seasonal allergic rhinitis, perennial allergic rhinitis, or chronic idopathic urticaria, in a human more 12 years old, by administering an amount of desloratadine, e. g. 2×2. 5 mg or 5 mg/day for a time sufficient to produce a geometric mean steady state maximum plasma concentration of desloratadine in the range of about 2. 90 ng/mL to about 4. 54 ng/mL, or a arithmetic mean steady state maximum plasma concentration of desloratadine in the range of about 3. 2 ng/mL to about 5. 0 ng/mL is disclosed.