Inventors:
Dennis M. Klinman - Potomac MD, US
Mei Zheng - Augusta GA, US
Barry T. Rouse - Knoxville TN, US
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
University of Tennessee Research Foundation - Knoxville TN
International Classification:
A61K 39/00, A61K 39/38, A61K 45/00, A61K 47/00, A01N 43/04
US Classification:
4241981, 4241841, 4242781, 514 44 R
Abstract:
This disclosure provides a method of inducing production of vascular endothelial growth factor by a cell. The method includes contacting the cell with a CpG oligonucleotide, thereby inducing the production of vascular endothelial growth factor by the cell. The disclosure further provides a method inducing neovascularization in a tissue. This method includes comprising introducing a CpG oligodeoxynucleotide into an area of the tissue wherein the formation of new blood vessels is desired, thereby inducing neovascularization in the area of the tissue.