Inventors:
Michael F. Clarke - Stanford CA, US
Stephen R. Quake - Stanford CA, US
Piero D. Dalerba - Palo Alto CA, US
Huiping Liu - Chicago IL, US
Anne A. Leyrat - San Carlos CA, US
Tomer Kalisky - Givat Shmuel, IL
Maximilian Diehn - Stanford CA, US
Michael Rothenberg - Menlo Park CA, US
Jianbin Wang - Millbrae CA, US
Neethan Lobo - San Francisco CA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
C12N 15/10
Abstract:
Methods are provided for diagnosis and prognosis of disease by analyzing expression of a set of genes obtained from single cell analysis. Classification allows optimization of treatment, and determination of whether on whether to proceed with a specific therapy, and how to optimize dose, choice of treatment, and the like. Single cell analysis also provides for the identification and development of therapies which target mutations and/or pathways in disease-state cells.