Inventors:
Matthias Kretzler - Ann Arbor MI, US
Patricia Logan - Vancouver, CA
International Classification:
A61K 31/7088, A61K 38/02, A61K 39/395, A61P 13/12
US Classification:
424130100, 514012000, 514044000
Abstract:
The invention relates to the treatment of renal diseases using modulators of integrin linked kinase. Methods of treatment as well as therapeutic agents including antisense, small molecules, catalytic peptides and antibodies are disclosed. The agents of the invention may also be used in combination with traditional therapies for renal disease including ACE inhibitors. An advantage of the invention is that it treats one of the causes of renal disease, rather than just ameliorating symptoms, and can help prevent the progression of renal disease to the point of acute renal failure.