Inventors:
Christopher French - Boston MA, US
Jon Aster - Lexington MA, US
Matthias Hofer - Chicago IL, US
James Bradner - Cambridge MA, US
Assignee:
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. - Boston MA
DANA-FARBER CANCER INSTITUTE - BOSTON MA
International Classification:
A61K 31/7088, A61K 31/16, A61K 31/395, A61K 31/403, A61K 31/4406, A61P 35/00
US Classification:
514 44 A, 514616, 514431, 514419, 514357
Abstract:
The present invention is directed, inter alia, to methods of treating NUT midline carcinoma (NMC) by administering compounds that promote increased histone acetylation. The invention also includes assay methods for determining the responsiveness of NMC to specific histone deacetylases and other compounds.