Inventors:
Glenn Dranoff - Lexington MA, US
Matthew Vanneman - Boston MA, US
Gordon Freeman - Brookline MA, US
Assignee:
Dana-Farber Cancer Institute, Inc. - Boston MA
International Classification:
A61K 39/395, A61N 5/00, A61P 37/04, A61P 35/00, A61P 35/02
Abstract:
Methods for cancer immunotherapy are provided. The methods involve the use of a chimeric molecule (e.g., fusion protein) comprising an NKG2D portion and an Fc portion, which binds one or more NKG2D ligands. The methods disclosed herein are useful for the treatment of cancer that is associated with abnormal expression of one or more NKG2D ligands.