Inventors:
Michael G. Kaplitt - New York NY
Matthew J. During - Weston CT
Assignee:
The Rockefeller University - New York NY
Yale University - New Haven CT
International Classification:
A01N 4304, A61K 3170, C12N 1563, C12N 1500
Abstract:
The invention relates to a method of delivering exogenous DNA to a target cell of the mammalian central nervous system using an adeno-associated virus (AAV)-derived vector. Also included in the invention are the AAV-derived vectors containing exogenous DNA which encodes a protein or proteins which treat nervous system disease, and a method of treating such disease.