Inventors:
Vinod Patel - Acton MA, US
Joseph Kim - Wayland MA, US
Stephanie Geuns-Meyer - Medford MA, US
Stuart Chaffee - Cambridge MA, US
Victor Cee - Mansfield MA, US
Brian Hodous - Cambridge MA, US
Steven Bellon - Wellesley MA, US
Jean-Christophe Harmange - Andover MA, US
Philip Olivieri - Medford MA, US
Maya Thaman - Ventura CA, US
Erin DiMauro - Cambridge MA, US
John Buchanan - Newton MA, US
David McGowan - Pierre, BE
Brian Albrecht - Cambridge MA, US
Holly Deak - Brookline MA, US
Jean Bemis - Arlington MA, US
Ryan White - Somerville MA, US
Matthew Martin - Arlington MA, US
Gregory Habgood - Merrimac MA, US
Paul Tempest - Brookline MA, US
Craig Masse - Cambridge MA, US
William Buckner - Arlington MA, US
Bradley Herberich - Newbury Park CA, US
Russell Graceffa - Hampton NH, US
Dawei Zhang - Thousand Oaks CA, US
Shimin Xu - Santa Barbara CA, US
Kelvin Sham - Thousand Oaks CA, US
Robert Rzasa - Ventura CA, US
James Falsey - Moorpark CA, US
Partha Chakrabarti - Simi Valley CA, US
Guo-Qiang Cao - Thousand Oaks CA, US
Susan Tomlinson - Boston MA, US
Liping Pettus - Thousand Oaks CA, US
Adrian Smith - Simi Valley CA, US
Nick Paras - Santa Monica CA, US
Gang Liu - Oak Park CA, US
Frenel DeMorin - Thousand Oaks CA, US
Andrew Tasker - Simi Valley CA, US
Anthony Reed - Oxnard CA, US
International Classification:
A61K 31/525, A61K 31/519, A61K 31/517
US Classification:
514251000, 514266100, 514264100, 544279000, 544284000, 544257000
Abstract:
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation, cancer and related conditions. The compounds have a general Formula I
wherein A, A, A, B, R, R, Rand Rare defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.