Inventors:
Michael L. Hutton - Newton MA, US
Matthew Charles Baker - Jacksonville FL, US
Jennifer Mae Gass - Atlantic Beach FL, US
Rosa Rademakers - Ponte Vedra FL, US
Jason Eriksen - Houston TX, US
Stuart M. Pickering-Brown - Derbyshire, GB
Ian Reid Alexander Mackenzie - Vancouver, CA
Howard Feldman - Vancouver, CA
Samir Kumar-Singh - Edegem, BE
Christine Van Broeckhoven - Edegem, BE
Marc Cruts - Antwerp, BE
Ashley Diane Cannon - Jacksonville FL, US
Assignee:
Mayo Foundation for Medical Education and Research - Rochester MN
The University of British Columbia - Vancouver
The University of Manchester - Manchester
VIB VZW - Zwijnaarde
Universiteit Antwerpen - Antwerp
International Classification:
C12Q 1/68
Abstract:
This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e. g. , dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.