Inventors:
Matthew Breyer - Nashville TN, US
International Classification:
A61K031/60, A61K031/401, A61K031/192, A61K031/05
US Classification:
514165000, 514569000, 514570000, 514423000, 514733000
Abstract:
The present invention relates to the use of COX-1 selective inhibitors to treat diabetic nephropathy. In particular, COX-1 inhibitors may be combined with standard insulin replacment therapy, and/or combined with ACE inhbitor therapy. The therapy is, in a specific embodiment, designed to inhibit systemic COX-1 activity, reflected by inhibition of platelet-stimulated thromboxane production, while not inhibiting macrophage PGE2 production.