Inventors:
Dean Y, Li - Salt Lake City UT, US
Matthew Smith - Salt Lake City UT, US
Andy Weyrich - Salt Lake City UT, US
Assignee:
UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT
International Classification:
A61K 38/17, C07K 14/47, C12N 5/078, A61P 7/02, A61P 7/00
US Classification:
514 138, 514 135, 514 149, 530350, 435375
Abstract:
Active agents, compositions, and methods for inhibiting and reversing platelet function are provided herein. In particular embodiments, the active agents provided herein inhibit or reverse platelet function. In particular embodiments, the compositions described herein are pharmaceutical formulations. Methods of inhibiting and reversing platelet function are also provided herein. In particular embodiments, methods as described herein include administration of a Sema3E polypeptide. Further, methods of treating pathologic conditions associated with platelet function (i.e., platelet activation) and methods of screening active agent candidates are also provided.