DR. MATKO KALAC, M.D., PH.D.
Osteopathic Medicine at 102 St, New York, NY
License number
New York 271101
Category
Osteopathic Medicine
Type
Medical Oncology
Address
Address
10 E 102Nd St, New York, NY 10029
Phone
(212) 241-6756
(212) 987-3100
(212) 731-5210 (Fax)
(212) 987-3100
(212) 731-5210 (Fax)
Professional information
Dr. Matko Kalac, New York NY - MD (Doctor of Medicine)
Specialties:
Hematology, Hematology & Oncology
Address:
550 1St Ave, New York 10016
(212) 263-5506 (Phone), (212) 263-7300 (Fax)
177 Fort Washington Ave, New York 10032
(212) 263-5506 (Phone), (212) 263-7300 (Fax)
177 Fort Washington Ave, New York 10032
Languages:
English
N-Quinolin-Benzensulfonamides And Related Compounds For The Treatment Of Cancer, Autoimmune Disorders And Inflammation
US Patent:
2014007, Mar 13, 2014
Filed:
Sep 6, 2013
Appl. No.:
14/020363
Inventors:
Owen O'Connor - Scarsdale NY, US
Matko Kalac - New York NY, US
Kristen Alison Rinderspacher - Bronx NY, US
Matko Kalac - New York NY, US
Kristen Alison Rinderspacher - Bronx NY, US
Assignee:
The Trustees of Columbia Unversity in the City of New York - New York NY
International Classification:
C07D 215/40, C07D 409/12
US Classification:
514314, 435475, 546171, 514311
Abstract:
The present invention relates to the NQBS class of molecules. It is based, at least in part, on the discovery that a representative group of compounds have been observed to inhibit nuclear translocation of NF-κB subunits. Without being bound by any particular theory, this inhibition of nuclear translocation may be mediated by either (i) binding of the NQBS or related compound to the C-terminus of the RHD, which specifically mediates the nuclear internalization; or (ii) NQBS-mediated stabilization of the dimer/IκB complex, disallowing dissociation of the active NF-κB monomers, and thus, inhibiting the generation of the subunits necessary to enter the nucleus. The NQBS class of molecules, and related molecules, may be used in therapeutic applications where inhibition of NF-κB translocation is beneficial, including but not limited to the treatment of cancer, autoimmune disorders, and inflammatory states.