Inventors:
Bert Vogelstein - Baltimore MD, US
Kenneth W. Kinzler - Bel Air MD, US
Hans Albertsen - Cupertino CA, US
Rakesh Anand - Sandbach, GB
Mary Carlson - Salt Lake City UT, US
Joanna Groden - Salt Lake City UT, US
Philip Hedge - Winsford, GB
Geoff Joslyn - Salt Lake City UT, US
Alexander Fred Markham - Crewe, GB
Yusuke Nakumura - Tokyo, JP
Andrew Thliveris - Salt Lake City UT, US
Raymond White - Salt Lake City UT, US
Assignee:
The Johns Hopkins University - Baltimore
Astrazeneca United Kingdom, Ltd. - London
Cancer Institute, Japanese, Foundation for Cancer Research - Tokyo
The University of Utah - Salt Lake City UT
International Classification:
C07K 16/30, A61K 39/395
US Classification:
5303879, 5303871, 5303877, 530828, 530806, 4241301, 4241381, 4241391, 4241741
Abstract:
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.