DR. MARY CORR, MD
Osteopathic Medicine at Arbor Dr, San Diego, CA

2004012, Jul 1, 2004

Sep 19, 2003

10/667208

Dennis Carson - La Jolla CA, US
Lorenzo Leoni - San Diego CA, US
Mary Corr - San Diego CA, US

A61K031/7052, A61K031/4745, A61K031/407, A61K031/675

514/023000, 514/081000, 514/291000, 514/381000, 514/411000

The present invention provides a therapeutic method to treat non-malignant diseases characterized by the excessive tissue growth, e.g., hyperplastic diseases, comprising administering to a mammal (e.g., human) afflicted with excessive tissue growth, an effective amount of a derivative of an indole compound of formula (I):formula (I): wherein Ris lower alkyl, (hydroxy)lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, phenyl, benzyl or 2-thienyl; R, R, Rand Rare the same or different and are each hydrogen or lower alkyl; each Ris individually hydrogen, lower alkyl, hydroxy, (hydroxy)lower alkyl, lower alkoxy, benzyloxy, lower alkanoyloxy, nitro or halo, Ris hydrogen, lower alkyl or lower alkenyl, X is oxy and thio, Y is carbonyl, —(CH)—, —(C-C)alkyl(CO)—, or —(CH)SO—; Z is hydroxy, lower alkoxy, (C-C)acyloxy, —N(R)(R), phenylamino, (-(4-pyridyl)(C-Calkoxy), (-((R)(R) amino)(C-Calkoxy), an amino acid ester of (-(HO)(C-C))alkoxy, —N(R)CH(R)COH, 1′-D-glucuronyloxy, —SOH, —POH, —N(NO)(OH), —SONH, —PO(OH)(NH), —OCHCHN(CH), or tetrazolyl; wherein Rand Rare each H, (C-C)alkyl or together with N are a 5- or 6-membered heterocyclic ring comprising 1-3 N(R), S or nonperoxide O; n is 0, 1, 2, or 3; wherein Rand Rare each H, (C-C)alkyl or together with N are a 5- or 6-membered heterocyclic ring comprising 1-3 N(R), S or nonperoxide O; each alkyl or phenyl group of R, R, R, R, R, R, Rand Z is optionally substituted with 1, 2, or 3 (C-C)alkyl groups; or a pharmaceutically acceptable salt thereof.

2007029, Dec 27, 2007

Dec 22, 2006

11/615396

Dennis Carson - La Jolla CA, US
Lorenzo Leoni - San Diego CA, US
Mary Corr - San Diego CA, US

A61K 31/407, A61K 31/496, A61K 31/56, A61P 35/00

514171000, 514252160, 514411000

The present invention provides a therapeutic method to treat non-malignant diseases characterized by the excessive tissue growth, e.g., hyperplastic diseases, comprising administering to a mammal (e.g., human) afflicted with excessive tissue growth, an effective amount of a derivative of an indole compound of formula (I):formula (I): wherein Ris lower alkyl, (hydroxy)lower alkyl, lower alkenyl, lower alkynyl, lower cycloalkyl, phenyl, benzyl or 2-thienyl; R, R, Rand Rare the same or different and are each hydrogen or lower alkyl; each Ris individually hydrogen, lower alkyl, hydroxy, (hydroxy)lower alkyl, lower alkoxy, benzyloxy, lower alkanoyloxy, nitro or halo, Ris hydrogen, lower alkyl or lower alkenyl, X is oxy and thio, Y is carbonyl, —(CH)—, —(C-C)alkyl(CO)—, or —(CH)SO—; Z is hydroxy, lower alkoxy, (C-C)acyloxy, —N(R)(R), phenylamino, (ω-(4-pyridyl)(C-Calkoxy), (ω-((R)(R) amino)(C-Calkoxy), an amino acid ester of (ω-(HO)(C-C))alkoxy, —N(R)CH(R)COH, 1′-D-glucuronyloxy, —SOH, —POH, —N(NO)(OH), —SONH, —PO(OH)(NH), —OCHCHN(CH), or tetrazolyl; wherein Rand Rare each H, (C-C)alkyl or together with N are a 5- or 6-membered heterocyclic ring comprising 1-3 N(R), S or nonperoxide O; n is 0, 1, 2, or 3; wherein Rand Rare each H, (C-C)alkyl or together with N are a 5- or 6-membered heterocyclic ring comprising 1-3 N(R), S or nonperoxide O; each alkyl or phenyl group of R, R, R, R,R, R, Rand Z is optionally substituted with 1, 2, or 3 (C-C)alkyl groups; or a pharmaceutically acceptable salt thereof.

7816352, Oct 19, 2010

Mar 10, 2006

11/885463

Dennis A. Carson - La Jolla CA, US
Howard B. Cottam - Escondido CA, US
Sylvie Barchéchath - Geneva, CH
Mary Patricia Corr - San Diego CA, US

The Regents of The University of California - Oakland CA

A61K 31/535, A61K 31/47, A61K 31/497, C07D 213/56, C07D 217/00, C07D 215/38

5142352, 51425311, 5142355, 514357, 514343, 51425306, 514314, 514311, 514307, 51425305, 544128, 544363, 544360, 544124, 5462764, 546159, 546201, 546145, 546338

The present invention provides compounds that act as selective agents to protect against unintentional cell death or tissue damage and can relieve side effects of cancer treatment such as, for example, oral mucositis, hair loss, diarrhea due to damage to the gastrointestinal epithelium, and myelosuppression. In addition, these compounds can be used to prevent premature cell death when the cell death is caused by signals from damaged cells, for example, signals generated as the result of a traumatic incident or an ischemic episode.

2005013, Jun 16, 2005

Sep 22, 2004

10/947849

Dennis Carson - La Jolla CA, US
Mary Corr - San Diego CA, US
John Loughlin - Headington, GB

REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

C12Q001/68, G01N033/53, G01N033/567, C07H021/04

435006000, 514044000, 435007200, 536024300

This invention provides methods to identify individuals predisposed to developing osteoarthritis, to diagnose osteoarthritis, and to monitor the progression of the disease. The method also provides methods to identify modulators of bone development that affect a wnt/fzd signaling pathway and methods to prevent or treat osteoarthritis by administering the modulator of bone development.